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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/48526
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Campo DCValorIdioma
dc.creatorEliane do Nascimentopt_BR
dc.creatorHelvécio Costa Menezespt_BR
dc.creatorRodrigo Ribeiro Resendept_BR
dc.creatorVânia Aparecida Mendes Goulartpt_BR
dc.creatorZenilda de Lourdes Cardealpt_BR
dc.date.accessioned2022-12-30T14:35:47Z-
dc.date.available2022-12-30T14:35:47Z-
dc.date.issued2019-
dc.citation.volume30pt_BR
dc.citation.issue10pt_BR
dc.citation.spage2136pt_BR
dc.citation.epage2143pt_BR
dc.identifier.doihttps://doi.org/10.21577/0103-5053.20190093pt_BR
dc.identifier.issn1678-4790pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/48526-
dc.description.resumoThis work presents the application of a simple and sensitive method developed for the simultaneous analysis of the levels of twenty two underivatizated free L-amino acids in plasma samples of preeclampsia patients by high performance liquid chromatography coupled to high-resolution mass spectrometer (LC-HRMS) using hydrophilic interaction liquid chromatography (HILIC) silica column. The linearity was evaluated in the range of 0.009 to 8.018 μmol L-¹ showing coefficients of determination (R²) in the range of 0.999 to 0.911 (p < 0.05). The intra- and inter-day precisions were above of 9.84 and 15.31, respectively. The limits of detection (LOD) and quantification (LOQ) were in the range of 0.003 to 0.683 μmol L-¹ and 0.009 to 2.276 μmol L-¹, respectively. The results of the investigation of free L-amino acids showed that the levels of GABA, Arg, Ser, Leu, Ile, Met, Val, Ala, Gly, Bet, His and Lys in plasma of patients with preeclampsia were significantly different from healthy patients.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of the Brazilian Chemical Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectL-amino acidspt_BR
dc.subjectBiomarkerspt_BR
dc.subjectPreeclampsiapt_BR
dc.subjectLC-HRMS-ESI-IT-TOFpt_BR
dc.subject.otherQuímica bioinorganicapt_BR
dc.subject.otherBioquímicapt_BR
dc.subject.otherQuímica inorgânicapt_BR
dc.subject.otherAminoácidospt_BR
dc.subject.otherMarcadores biológicospt_BR
dc.subject.otherPre-eclampsiapt_BR
dc.subject.otherCromatografia liquidapt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.titleDetermination of amino acids in plasma samples of preeclampsia patients by liquid chromatography coupled to high-resolution mass spectrometrypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttp://static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2019-0048AR_BrazWoman.pdfpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5759-612Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2003-0739pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3234-8357pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1383-6299pt_BR
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