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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51362
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dc.creatorDaniela Fernanda de Freitaspt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorLuciana Mendes Araújo Borémpt_BR
dc.creatorValéria Mafrapt_BR
dc.creatorDiego Vicente da Costapt_BR
dc.creatorTheles Oliveira Costapt_BR
dc.creatorClaudia Regina Vieirapt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2023-03-30T12:53:09Z-
dc.date.available2023-03-30T12:53:09Z-
dc.date.issued2021-
dc.citation.volume44pt_BR
dc.citation.spage23pt_BR
dc.citation.epage30pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.phytol.2021.04.014pt_BR
dc.identifier.issn1874-3900pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51362-
dc.description.resumoAcosmium dasycarpum (Vog.) Yakovlev, is a Brazilian medicinal plant, belonging to the Fabaceae family known as "Unha D’anta", exclusively found in the Cerrado (Brazilian Savanna) region, and has already shown tranquilizing, hypotensive, antineoplastic and antiseptic activities reported by traditional medicine and scientific evidences. Considering that overweight and obesity are an increasing worldwide health problem, the present study aimed to investigate the anti-obesity effect of bark powder and the dichloromethane extract of A. dasycarpum compared to the most abundant bioactive component (lupeol) using an obese mice model induced by a high-fat diet (HFD). The extracts derived from root bark of A. dasycarpum were characterized (phytochemical screening and GC–MS analysis) and their biological effects tested. After obesity inducement, Swiss male mice were treated with bark root powder or dichloromethane extract or lupeol (all treatments with 10 mg/1000 g/body weight dose) during 14 days. Oral glucose tolerance, insulin sensitivity, lipid profile, histology, ultrasound imaging and adipogenic genes expression were evaluated. The main results showed that A. dasycarpum root bark powder and dichloromethane extract reduced body weight and adiposity as evidenced by histology and ultrasound imaging. We also verified an improved glycemic and lipid profiles by reducing triglycerides, LDL and increasing HDL. The A. dasycarpum treatment suppressed the expression of CCAAT/enhancer-binding protein (C/EBPα), fatty acid translocase (FAT), and stearoyl coenzyme A desaturase-1 (SCD-1) adipogenic genes when compared to the obese control group. In conclusion, A. dasycarpum root bark showed a potential to be an accessible adjuvant treatment for obesity.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPhytochemistry Letters-
dc.rightsAcesso Restritopt_BR
dc.subject.otherPlantas medicinaispt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherFígado gordurosopt_BR
dc.subject.otherDiabetespt_BR
dc.titleAcosmium dasycarpum (Vog.) Yakovlev root bark reduces obesity induced by hypercaloric diet in mice: acosmium dasycarpum improves obesitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1874390021000926?via%3Dihubpt_BR
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