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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51816
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dc.creatorLeonardo da Silva Netopt_BR
dc.creatorAngélica Faleiros da Silva Maiapt_BR
dc.creatorAdriana Martins Godinpt_BR
dc.creatorPaulo Sérgio de Almeida Augustopt_BR
dc.creatorRaissa Lima Gonçalves Pereirapt_BR
dc.creatorSordaini Maria Caligiornept_BR
dc.creatorRosemeire Brondi Alvespt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorGisele Assis Castro Goulartpt_BR
dc.creatorFelipe Terra Martinspt_BR
dc.creatorMaila de Castro Lourenço das Nevespt_BR
dc.creatorFrederico Duarte Garciapt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.date.accessioned2023-04-11T20:37:15Z-
dc.date.available2023-04-11T20:37:15Z-
dc.date.issued2022-05-
dc.citation.volume38pt_BR
dc.citation.spage285pt_BR
dc.citation.epage298pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jare.2021.09.003pt_BR
dc.identifier.issn20901232pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51816-
dc.description.resumoIntroduction Cocaine use disorder is a significant public health issue without a current specific approved treatment. Among different approaches to this disorder, it is possible to highlight a promising immunologic strategy in which an immunogenic agent may reduce the reinforcing effects of the drug if they are able to yield sufficient specific antibodies capable to bind cocaine and/or its psychoactive metabolites before entering into the brain. Several carriers have been investigated in the anti-cocaine vaccine development; however, they generally present a very complex chemical structure, which potentially hampers the proper assessment of the coupling efficiency between the hapten units and the protein structure. Objectives The present study reports the design, synthesis and preclinical evaluation of two novel calix[n]arene-based anti-cocaine immunogens (herein named as V4N2 and V8N2) by the tethering of the hydrolysis-tolerant hapten GNE (15) on calix[4]arene and calix[8]arene moieties. Methods The preclinical assessment corresponded to the immunogenicity and dose–response evaluation of V4N2 and V8N2. The potential of the produced antibodies to reduce the passage of cocaine analogue through the blood–brain-barrier (BBB), modifying its biodistribution was also investigated. Results Both calix[n]arene-based immunogens elicited high titers of cocaine antibodies that modified the biodistribution of a cocaine radiolabeled analogue (99mTc-TRODAT-1) and decreased cocaine-induced behavior, according to an animal model. Conclusion The present results demonstrate the potential of V4N2 and V8N2 as immunogens for the treatment of cocaine use disorder.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Advanced Research-
dc.rightsAcesso Abertopt_BR
dc.subjectCocainept_BR
dc.subjectCrackpt_BR
dc.subjectChemical addictionpt_BR
dc.subjectCalixarenespt_BR
dc.subjectImmunotherapypt_BR
dc.subjectTRODAT-1pt_BR
dc.subject.otherCocaínapt_BR
dc.subject.otherDependência químicapt_BR
dc.subject.otherImunoterapiapt_BR
dc.titleCalix[n]arene-based immunogens: a new non-proteic strategy for anti-cocaine vaccinept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2090123221001715pt_BR
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