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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/52599
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Campo DCValorIdioma
dc.creatorGabriel Silva Marques Borgespt_BR
dc.creatorElaine Maria de Souza Fagundespt_BR
dc.creatorLucas Antônio Miranda Ferreirapt_BR
dc.creatorPedro Henrique Dias Moura Prazerespt_BR
dc.creatorÂngelo Malachias de Souzapt_BR
dc.creatorMaria Irene Yoshidapt_BR
dc.creatorJosé Mário Carneiro Vilelapt_BR
dc.creatorAline Teixeira Maciel e Silvapt_BR
dc.creatorMariana Silva Oliveirapt_BR
dc.creatorDawidson Assis Gomespt_BR
dc.creatorMargareth Spangler Andradept_BR
dc.date.accessioned2023-04-27T18:25:50Z-
dc.date.available2023-04-27T18:25:50Z-
dc.date.issued2021-
dc.citation.volume57pt_BR
dc.citation.spage1pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/s2175-97902020000418497pt_BR
dc.identifier.issn2175-9790pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52599-
dc.description.resumoSclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences-
dc.rightsAcesso Abertopt_BR
dc.subjectCancerpt_BR
dc.subjectSclareolpt_BR
dc.subjectSolid lipid nanoparticlespt_BR
dc.subjectNanostructured lipid carrierspt_BR
dc.subjectSmall-angle X-ray scatteringpt_BR
dc.subject.otherCâncerpt_BR
dc.subject.otherNanopartículaspt_BR
dc.subject.otherLipídiospt_BR
dc.titleNanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell linespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bjps/a/hrgfv38NNnJqwvqXtQVG9Dv/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7360-8231pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0539-9052pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2474-5536pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1933-3230pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7714-991Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0412-1622pt_BR
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