Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/52883| Type: | Artigo de Periódico |
| Title: | Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety |
| Other Titles: | Terapia hormonal após cirurgia redutora de risco em pacientes com mutação BRCA1/BRCA2: evidências dos benefícios potenciais e segurança |
| Authors: | Agnaldo Lopes da Silva Filho Eduardo Batista Cândido Gabriella Martins Carvalho Larissa Cristelli de Sena Lívia Passini Guimarães Gomes Marcos Flávio Habib Valério Raíssa Isabelle Leão Martins |
| Abstract: | Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO. |
| Subject: | Mutação Terapia de reposição de estrogênios Salpingostomia Ovariectomia Salpingo-ooforectomia Neoplasias da mama |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1590/1806-9282.66.8.1134 |
| URI: | http://hdl.handle.net/1843/52883 |
| Issue Date: | Aug-2020 |
| metadata.dc.url.externa: | https://www.scielo.br/j/ramb/a/cxBbmG4y5NQmftjqfQddWdk/?format=html&lang=en |
| metadata.dc.relation.ispartof: | Revista da Associação Médica Brasileira |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Hormone therapy after risk-reducing surgery in patients with BRCA1BRCA2 mutation evaluation of potential benefits and safety.pdf | 271.04 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.