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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/53958
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Campo DCValorIdioma
dc.creatorAriane Barros Dinizpt_BR
dc.creatorMaísa Mota Antunespt_BR
dc.creatorViviane Aparecida de Souza Lacerdapt_BR
dc.creatorBrenda Naemi Nakagakpt_BR
dc.creatorMaria Alice Freitas Lopespt_BR
dc.creatorHortência Maciel de Castro-Oliveirapt_BR
dc.creatorMatheus Silvério Mattospt_BR
dc.creatorKassiana Mafra Bicalhopt_BR
dc.creatorCamila Dutra Moreira de Mirandapt_BR
dc.creatorKaren Marques de Oliveira Costapt_BR
dc.creatorMateus Eustáquio de Moura Lopespt_BR
dc.creatorDébora Moreira Alvarengapt_BR
dc.creatorRaquel Carvalho-Gontijopt_BR
dc.creatorSarah Cozzer Marchesipt_BR
dc.creatorDebora Romualdo Lacerdapt_BR
dc.creatorAlan Moreira de Araújopt_BR
dc.creatorÉrika de Carvalhopt_BR
dc.creatorBruna Araújo Davidpt_BR
dc.creatorMônica Morais Santospt_BR
dc.creatorCristiano Xavier Limapt_BR
dc.creatorJuliana Assis Silva Gomespt_BR
dc.creatorTereza Cristina Minto Fontes Calpt_BR
dc.creatorBruna Roque de Souzapt_BR
dc.creatorCláudia Alves Coutopt_BR
dc.creatorLuciana Costa Fariapt_BR
dc.creatorPaula Vieira Teixeira Vidigalpt_BR
dc.creatorAdaliene Versiane Matos Ferreirapt_BR
dc.creatorSridhar Radhakrishnnanpt_BR
dc.creatorMatthew Riccipt_BR
dc.creatorAndré Gustavo Oliveirapt_BR
dc.creatorRafael Machado Rezendept_BR
dc.creatorGustavo Batista Menezespt_BR
dc.date.accessioned2023-05-25T20:03:31Z-
dc.date.available2023-05-25T20:03:31Z-
dc.date.issued2020-
dc.citation.volume2pt_BR
dc.citation.issue4pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jhepr.2020.100117pt_BR
dc.identifier.issn2589-5559pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/53958-
dc.description.resumoBackground & Aims: The precise determination of non-alcoholic fatty liver disease (NAFLD) onset is challenging. Thus, the initial hepatic responses to fat accumulation, which may be fundamental to our understanding of NAFLD evolution and clinical outcomes, are largely unknown. Herein, we chronologically mapped the immunologic and metabolic changes in the liver during the early stages of fatty liver disease in mice and compared this with human NAFLD samples. Methods: Liver biopsies from patients with NAFLD (NAFLD activity score [NAS] 2–3) were collected for gene expression profiling. Mice received a high-fat diet for short periods to mimic initial steatosis and the hepatic immune response was investigated using a combination of confocal intravital imaging, gene expression, cell isolation, flow cytometry and bone marrow transplantation assays. Results: We observed major immunologic changes in patients with NAS 2–3 and in mice in the initial stages of NAFLD. In mice, these changes significantly increased mortality rates upon drug-induced liver injury, as well as predisposing mice to bacterial infections. Moreover, deletion of Toll-like receptor 4 in liver cells dampened tolerogenesis, particularly in Kupffer cells, in the initial stages of dietary insult. Conclusion: The hepatic immune system acts as a sentinel for early and minor changes in hepatic lipid content, mounting a biphasic response upon dietary insult. Priming of liver immune cells by gut-derived Toll-like receptor 4 ligands plays an important role in liver tolerance in initial phases, but continuous exposure to insults may lead to damage and reduced ability to control infections.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJHEP Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectNAFLDpt_BR
dc.subjectLiverpt_BR
dc.subjectSteatosispt_BR
dc.subjectImmune systempt_BR
dc.subjectDietpt_BR
dc.subjectMetabolismpt_BR
dc.subjectIn vivo imagingpt_BR
dc.subjectImmunitypt_BR
dc.subject.otherHepatopatia gordurosa não alcoólicapt_BR
dc.subject.otherFígadopt_BR
dc.subject.otherSistema Imunitáriopt_BR
dc.subject.otherDietapt_BR
dc.subject.otherMetabolismopt_BR
dc.subject.otherImunidadept_BR
dc.titleImaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLDpt_BR
dc.title.alternativeA imagem e a fenotipagem imunometabólica revelam alterações na resposta imune hepática nas fases iniciais da NAFLDpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2589555920300513?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3137-991Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4600-7593pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4926-0618pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9163-6279pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0184-6433pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4779-8972pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4779-8972pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8730-7336pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7909-6970pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5157-159Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7724-890Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2256-8652pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8307-0810pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3998-8012pt_BR
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