1. Repositório Institucional da UFMG
2. Publicações Científicas e Culturais
3. Artigo de Periódico

Type:	Artigo de Periódico
Title:	The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis
Authors:	Rafael de Pinhoqueiroz Daniele Viana Inês Felipe Telöken Diligenti Victor Haygert Schnor Jacobo Melamed Wesley Ribeiro Campos Daniel Vítor de Vasconcelos Santos
Abstract:	Background: Syphilitic uveitis is reemerging globally, may lead to any type of intraocular inflammation, and is potentially sight-threatening. We aim to characterize clinical features and prognostic factors in patients with syphilitic posterior uveitis. Methods: Retrospective chart review at two tertiary university-based referral centers in Brazil. Clinical data, laboratory results, and treatment outcomes were analyzed. Statistical analysis was performed using Fisher’s exact test for categorical variables and Mann-Whitney U test for continuous variables. Results: Forty-four patients (81 eyes) were consecutively diagnosed with syphilitic posterior uveitis between March 2011 and April 2013.Thirty-one were male (70.5%) and the mean age was 43.8 years (range 15–81). HIV confection was disclosed in 12 patients (29.3%). The most prevalent finding was vitritis (85.2%), followed by retinal involvement (76.4%) and optic disc abnormalities (63.5%). After treatment, mean visual acuity improved from 1.2 (20/320) to 0.6 (20/80; median 20/30), but 19 eyes (23.5%) persisted with ≤ 1.0 (20/200). Factors associated with final visual acuity ≤ 1.0 despite therapy were prior use of systemic corticosteroids (p = 0.001), higher Venereal Disease Research Laboratory titers (p = 0.004), longer duration of symptoms (p = 0.024), and worse initial VA (p < 0.001). Conclusions: Syphilitic uveitis is reemerging. Delayed diagnosis and inadvertent use of systemic corticosteroids are potentially modifiable prognostic factors to be considered for possibly improving outcomes.
Subject:	Epidemiologia Prognóstico Infecções Sexualmente Transmissíveis Sífilis Uveíte
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1186/s12348-019-0169-8
URI:	http://hdl.handle.net/1843/54630
Issue Date:	2019
metadata.dc.url.externa:	https://joii-journal.springeropen.com/articles/10.1186/s12348-019-0169-8
metadata.dc.relation.ispartof:	Journal of Ophthalmic Inflammation and Infection
Appears in Collections:	Artigo de Periódico

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.