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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55202
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dc.creatorAloísio Miguel Garciapt_BR
dc.creatorFelipe Lima Magalhãespt_BR
dc.creatorJaqueline s Soarespt_BR
dc.creatorEduardo Paulino Juniorpt_BR
dc.creatorMário f r de Limapt_BR
dc.creatorMarcelo Mamedept_BR
dc.creatorAna m de Paulapt_BR
dc.date.accessioned2023-06-21T19:50:09Z-
dc.date.available2023-06-21T19:50:09Z-
dc.date.issued2018-02-02-
dc.citation.volume4pt_BR
dc.citation.issue2pt_BR
dc.identifier.doi10.1088/2057-1976/aaa379pt_BR
dc.identifier.issn20571976pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55202-
dc.description.resumoOptical microscopy has been one of the most important tools for visualizing biological samples since the seventeenth century. Recently, with the advances in femtosecond laser technology, all the nonlinear optical processes have now been included as optical microscopy methods, and second harmonic generation (SHG) microscopy has emerged as a powerful new optical imaging tool with applications in medicine and biology. Here we use SHG microscopy to obtain images of 76 prostate biopsies on histological slides. Multiple samples from the excised prostates of patients who underwent a radical prostatectomy were evaluated. The samples were collected from prostate positions as in needle biopsy procedures. The results show the collagen fiber architecture among malignant acini, and analysis of the fiber orientation in the images reveals that the collagen fibers become more aligned at higher malignancy grades. Furthermore, we find that the degree of fiber alignment correlates directly with the Gleason patterns.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEMpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomedical Physics & Engineering Express-
dc.rightsAcesso Restritopt_BR
dc.subjectOptical Imagingpt_BR
dc.subjectSecond harmonic generationpt_BR
dc.subjectProstatept_BR
dc.subjectBiopsiespt_BR
dc.subject.otherImagem Ópticapt_BR
dc.subject.otherMicroscopia de Geração do Segundo Harmônicopt_BR
dc.subject.otherProstátapt_BR
dc.subject.otherBiópsiapt_BR
dc.titleSecond harmonic generation imaging of the collagen architecture in prostate cancer tissuept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://iopscience.iop.org/article/10.1088/2057-1976/aaa379pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6157-6511pt_BR
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