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http://hdl.handle.net/1843/55300| Type: | Artigo de Periódico |
| Title: | Early serum biomarker networks in infants with distinct retinochoroidal lesion status of congenital toxoplasmosis |
| Authors: | Thádia Evelynde Araújo Daniel Vítor de Vasconcelos Santos José Nélio Januário Andréa Teixeira-carvalho Ricardo Wagner Almeida Vitor Eloisa Amália Vieira Ferro Olindo Assis Martins-filho Jordana Grazziela Coelho-dos-reis Samantha Ribeiro Béla Ana Carolina Aguiar Vasconcelos Carneiro Anderson Silva Machado Ludmila Melo Cardoso Ágata Lopes Ribeiro Michelle Hallais França Dias Gláucia Manzan Queiroz Andrade |
| Abstract: | The present study characterized the early changes in the serum chemokines/cytokine signatures and net works in infants with congenital-toxoplasmosis/(TOXO) as compared to non-infected-controls/(NI).TOXO were subgrouped according to the retinochoroidal lesion status as no-lesion/(NL), active-lesion/(ARL), active/cicatricial-lesion/(ACRL) and cicatricial-lesion/(CRL). The results showed that TOXO displayprominent chemokine production mediated by IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and RANTES/CCL5. Additionally, TOXO is accompanied by mixed proinflammatory/regulatory cytokine pattern mediated by IL-6, IFN-c, IL-4, IL-5 and IL-10. While TNF appears as a putative biomarker for NL and IFN-c/IL-5 as immunological features for ARL, IL-10 emerges as a relevant mediator in ACRL/CRL. IL-8/CXCL8 and IP-10/CXCL10 are broad-spectrum indicators of ocular disease, whereas TNF is a NL biomarker, IFN-c and MIG/CXCL9 point out to ARL; and IL-10 is highlighted as a genuine serum biomarker of ACRL/CRL.The network analysis demonstrated a broad chemokine/cytokine crosstalk with divergences in the molecular signatures in patients with different ocular lesions during congenital toxoplasmosis. |
| Subject: | Toxoplasmose Congênita Coriorretinopatia de Birdshot Crianças Biomarcadores Farmacológicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MICROBIOLOGIA ICB - DEPARTAMENTO DE PARASITOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1016/j.cyto.2017.02.018 |
| URI: | http://hdl.handle.net/1843/55300 |
| Issue Date: | 28-Feb-2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S1043466617300510?via%3Dihub |
| metadata.dc.relation.ispartof: | Cytokine |
| Appears in Collections: | Artigo de Periódico |
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