1. Repositório Institucional da UFMG
2. Publicações Científicas e Culturais
3. Artigo de Periódico

Type:	Artigo de Periódico
Title:	Prognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease
Authors:	Maria Betânia Solis Resende Maria do Carmo Pereira Nunes Teresa Cristina a Ferrari Christiano g Araújo Maria Carmen m. Vasconcelos Julia Teixeira Tupinambás Rebeca Coeli Teodoro Maciel Dias Flavio Coelho Barros José Nélio Januário Márcia Melo Barbosa
Abstract:	Cardiovascular complications have been increasingly detected in patients with sickle cell disease (SCD). Two-dimensional speckle-tracking echocardiography (STE) detects early myocardial changes in a number of pathophysiological processes, which may be useful in SCD. This study was designed to examine the value of STE in predicting clinical outcome in adult patients with SCD. A total of 219 patients, mean age 33±12 years were prospectively enrolled. Several clinical, laboratory and echocardiographic variables including left ventricular global longitudinal strain (LVGLS) by STE were assessed. The endpoint was a composite of the following events: (1) all-cause mortality, (2) three or more acute painful episodes that require hospitalization in one year, (3) acute chest syndrome and (4) hospitalization due to disease complication. The majority of the patients had enlargement of LV and left atrial (LA) with preserved ejection fraction. During the mean follow-up of 30 months, 69 patients (32%) had reached the endpoint, including eight deaths (3.7%). No diference was observed in the parameters of diastolic function comparing the patients with and without events. LVGLS ranged from −12.25 to−25.44 (mean−20.26±2.5), with higher values in the patients who had events compared with those who did not. In the multivari able analysis, higher LVGLS values were associated with adverse events (adjusted OR 1.25; 95% CI 1.04–1.51; p=0.021), independently of the TR maximal velocity and LV ejection fraction. In patients with SCD, higher LV global longitudinal strain was a predictor of adverse outcome, independently of age, TR velocity and LV function.
Subject:	Anemia Falciforme Deformação Longitudinal Global Resultado do Tratamento
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1007/s10554-020-01924-3
URI:	http://hdl.handle.net/1843/55441
Issue Date:	3-Jul-2020
metadata.dc.url.externa:	https://link.springer.com/article/10.1007/s10554-020-01924-3
metadata.dc.relation.ispartof:	The International Journal of Cardiovascular Imaging
Appears in Collections:	Artigo de Periódico

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.