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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55553
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dc.creatorVictor Coutinho Bastospt_BR
dc.creatorLiséte Celina Langept_BR
dc.creatorAdriana Nori de Macedopt_BR
dc.creatorGisele André Baptista Canutopt_BR
dc.creatorCarolina Cavaliéri Gomespt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorJéssica Gardone Vitóriopt_BR
dc.creatorRoberta Rayra Martins-chavespt_BR
dc.creatorFlávia Leite-Limapt_BR
dc.creatorYuri Abner Rocha Lebronpt_BR
dc.creatorVictor Rezende Moreirapt_BR
dc.creatorFilipe Fideles Duarte-Andradept_BR
dc.creatorThaís Dos Santos Fontes Pereirapt_BR
dc.creatorLucilaine Valéria de Souza Santospt_BR
dc.date.accessioned2023-06-29T17:52:13Z-
dc.date.available2023-06-29T17:52:13Z-
dc.date.issued2021-
dc.citation.volume2pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doihttps://doi.org/10.3389/froh.2021.677731pt_BR
dc.identifier.issn2673-4842pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55553-
dc.description.resumoAging is not a matter of choice; it is our fate. The “time-dependent functional decline that affects most living organisms” is coupled with several alterations in cellular processes, such as cell senescence, epigenetic alterations, genomic instability, stem cell exhaustion, among others. Age-related morphological changes in dental follicles have been investigated for decades, mainly motivated by the fact that cysts and tumors may arise in association with unerupted and/or impacted teeth. The more we understand the physiology of dental follicles, the more we are able to contextualize biological events that can be associated with the occurrence of odontogenic lesions, whose incidence increases with age. Thus, our objective was to assess age-related changes in metabolic pathways of dental follicles associated with unerupted/impacted mandibular third molars from young and adult individuals. For this purpose, a convenience sample of formalin-fixed paraffin-embedded (FFPE) dental follicles from young (<16 y.o., n = 13) and adult (>26 y.o., n = 7) individuals was selected. Samples were analyzed by high-performance liquid chromatography-mass spectrometry (HPLC-MS)-based untargeted metabolomics. Multivariate and univariate analyses were conducted, and the prediction of altered pathways was performed by mummichog and Gene Set Enrichment Analysis (GSEA) approaches. Dental follicles from young and older individuals showed differences in pathways related to C21-steroid hormone biosynthesis, bile acid biosynthesis, galactose metabolism, androgen and estrogen biosynthesis, starch and sucrose metabolism, and lipoate metabolism. We conclude that metabolic pathways differences related to aging were observed between dental follicles from young and adult individuals. Our findings support that similar to other human tissues, dental follicles associated with unerupted tooth show alterations at a metabolic level with aging, which can pave the way for further studies on oral pathology, oral biology, and physiology.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA SANITÁRIA E AMBIENTALpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Oral Healthpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAgingpt_BR
dc.subjectDental folliclept_BR
dc.subjectDental sacpt_BR
dc.subjectDevelopmental biologypt_BR
dc.subjectOral pathologypt_BR
dc.subjectUntargeted metabolomicspt_BR
dc.subjectLC-MSpt_BR
dc.subject.otherCélulas - Envelhecimentopt_BR
dc.subject.otherDentes - Doençaspt_BR
dc.subject.otherBiologia do desenvolvimentopt_BR
dc.subject.otherBoca - Doenças - Diagnósticopt_BR
dc.subject.otherCromatografia líquidapt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.titleAge-related metabolic pathways changes in dental follicles: a pilot studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/froh.2021.677731/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4125-3755pt_BR
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