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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55714
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dc.creatorElenapérez'nadalespt_BR
dc.creatorRanganathan n. Iyerpt_BR
dc.creatorz. Koçak Tufanpt_BR
dc.creatore. Kazakpt_BR
dc.creatorm. Davidpt_BR
dc.creatore. Leasept_BR
dc.creatorn. Nestorovapt_BR
dc.creatorg. Cornagliapt_BR
dc.creatorm. Akovapt_BR
dc.creatorSeema Methapt_BR
dc.creatorElisa Grazia Calvipt_BR
dc.creatorE.m. Seminaript_BR
dc.creatorMaristela Pinheiro Freirept_BR
dc.creatorj. Carratalápt_BR
dc.creatora. Domínguezpt_BR
dc.creatore. Corderopt_BR
dc.creatorJ.a. Lepept_BR
dc.creatorm. Montejopt_BR
dc.creatore. Merino de Lucaspt_BR
dc.creatorB.m. Erikssonpt_BR
dc.creatorc. Van Deldenpt_BR
dc.creatoro. Manuelpt_BR
dc.creatorh. Arslanpt_BR
dc.creatorMario Tumbarellopt_BR
dc.creatorMarco Falconept_BR
dc.creatorMario Fernández'ruizpt_BR
dc.creatorJosé María Costa'mateopt_BR
dc.creatorMeenakshi m. Ranapt_BR
dc.creatorTania Mara Varejão Strabellipt_BR
dc.creatorMical Paulpt_BR
dc.creatorBelén Gutiérrez'gutiérrezpt_BR
dc.creatorMaría Carmen Fariñaspt_BR
dc.creatorWanessa Trindade Clementept_BR
dc.creatorEmmanuel Roilidespt_BR
dc.creatorPatricia Muñoz Garcíapt_BR
dc.creatorLaurent Dewispelaerept_BR
dc.creatorBelén Loechespt_BR
dc.creatorWarren Lowmanpt_BR
dc.creatorBan Hock Tanpt_BR
dc.creatorRosa Escudero'sánchezpt_BR
dc.creatorMarta Bodro Marimontpt_BR
dc.creatorAlejandra m. Naterapt_BR
dc.creatorPaolo Antonio Grossipt_BR
dc.creatorFabio Soldanipt_BR
dc.creatorFiliz Gunserenpt_BR
dc.creatorNina Nestorovapt_BR
dc.creatorÁlvaro Pascualpt_BR
dc.creatorLuis Martínez'martínezpt_BR
dc.creatorJosé María Aguadopt_BR
dc.creatorJesús Rodríguez'bañopt_BR
dc.creatorJulián Torre'cisnerospt_BR
dc.creatorA.t. Wan Songpt_BR
dc.creatorEdson Abdalapt_BR
dc.creatorw. Andrauspt_BR
dc.creatorL.a. Carneiro D'albuquerquept_BR
dc.creatore. David'netopt_BR
dc.creatorf. Jota de Paulapt_BR
dc.creatorf. Rossipt_BR
dc.creatord. Ostranderpt_BR
dc.creatorr. Averypt_BR
dc.creatorm. Rizzipt_BR
dc.creatorA.r. Lositopt_BR
dc.creatorf. Raffaellipt_BR
dc.creatorMaira Reina Magalhãespt_BR
dc.creatorp. Del Giacomopt_BR
dc.creatorg. Tiseopt_BR
dc.creatorj. Lora'tamayopt_BR
dc.creatorr San'juanpt_BR
dc.creatori. Gracia'ahufingerpt_BR
dc.creatorj. Castónpt_BR
dc.creatorY.a. Ruizpt_BR
dc.creatorD.r. Altmanpt_BR
dc.creatorS.v. Campospt_BR
dc.creatorn. Bar'sinaipt_BR
dc.creatorAlessandra Mularonipt_BR
dc.creatorf. Koppelpt_BR
dc.creatorf. Arnaiz de Las Revillas Almajanopt_BR
dc.creatorc. González Ricopt_BR
dc.creatorm. Fernández Martínezpt_BR
dc.creatorP.h.o. Mourãopt_BR
dc.creatorF.a. Nevespt_BR
dc.creatorJanita Ferreirapt_BR
dc.creatora. Pyrpasopouloupt_BR
dc.creatore. Iosifidispt_BR
dc.creatori. Romiopoulospt_BR
dc.creatorFrancesco Monacopt_BR
dc.creatorM.v. Mineropt_BR
dc.creatorc Sánchez'carrillopt_BR
dc.creators. Lardopt_BR
dc.creatorj. Coussementpt_BR
dc.creatorm. Dodémontpt_BR
dc.creatork. Jiayunpt_BR
dc.creatorp. Martín'dávilapt_BR
dc.creatorj. Fortúnpt_BR
dc.creatorm. Almelapt_BR
dc.creatora. Morenopt_BR
dc.creatorLigia Camera Pierrottipt_BR
dc.creatorl. Linarespt_BR
dc.creatorD.d. Gasperinapt_BR
dc.creatorM.l. Balsamopt_BR
dc.creatorc Rovellipt_BR
dc.creatore. Conciapt_BR
dc.creators. Chiesipt_BR
dc.creatorD.n. Salernopt_BR
dc.creatord. Oguncpt_BR
dc.creatorb. Pilmispt_BR
dc.date.accessioned2023-07-03T23:01:37Z-
dc.date.available2023-07-03T23:01:37Z-
dc.date.issued2019-
dc.citation.volume9pt_BR
dc.citation.spage1629pt_BR
dc.citation.epage1641pt_BR
dc.identifier.doi10.1111/ajt.15769pt_BR
dc.identifier.issn16006135pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55714-
dc.description.resumoTreatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multina tional, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the fol lowing variables: INCREMENT-CPE mortality score ≥8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score ≥8 and CMV disease (minus 7 points). This score showed an area under the receiver operat ing characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combi nation therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortal ity risk strata. A score-based algorithm is provided for therapy guidance.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAmerican Journal of Transplantation-
dc.rightsAcesso Abertopt_BR
dc.subjectAntibiotic drug resistancept_BR
dc.subjectClinical research/practicept_BR
dc.subjectInfection and infectious agents-bacterialpt_BR
dc.subjectInfectious diseasept_BR
dc.subjectOrgan transplantation in generalpt_BR
dc.subject.otherFarmacorresistência Fúngicapt_BR
dc.subject.otherPesquisa em Enfermagem Clínicapt_BR
dc.subject.otherInfectologiapt_BR
dc.subject.otherTransplante de orgãospt_BR
dc.titlePredictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopeniapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1600613522223624?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0848-3740pt_BR
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