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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56051
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dc.creatorLucas Resende Dutra Sousapt_BR
dc.creatorCláudia Martins Carneiropt_BR
dc.creatorAna Paula Moreira Barbozapt_BR
dc.creatorBernardo Ruegger Almeida Nevespt_BR
dc.creatorPolicarpo Ademar Sales Juniorpt_BR
dc.creatorSilvane Maria Fonseca Murtapt_BR
dc.creatorKátia Monteiro Novackpt_BR
dc.creatorViviane Martins Rebello dos Santospt_BR
dc.creatorMaria Luíza Schaefer Azevedopt_BR
dc.creatorDayana Ferreira Rochapt_BR
dc.creatorÂngela Leão Andradept_BR
dc.creatorTatiane Roquete Amparopt_BR
dc.creatorOrlando David Henrique dos Santospt_BR
dc.creatorJanaina Brandão Seibertpt_BR
dc.creatorLuciano R. Pereirapt_BR
dc.creatorPaula Melo de Abreu Vieirapt_BR
dc.date.accessioned2023-07-11T11:59:06Z-
dc.date.available2023-07-11T11:59:06Z-
dc.date.issued2021-
dc.citation.volume32pt_BR
dc.citation.issue6pt_BR
dc.citation.spage1162pt_BR
dc.citation.epage1172pt_BR
dc.identifier.doihttps://dx.doi.org/10.21577/0103-5053.20210017pt_BR
dc.identifier.issn1678-4790pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56051-
dc.description.resumoSelecting a polymer depends on its characteristics, the properties of the drug and of the remaining ingredients in the formulation. The drug, when incorporated into a polymeric matrix, can show several advantages when compared with its conventional form. In this context, this work describes the preparation and characterization of polyethylene glycol (PEG 4000) and its derivative particles loaded with benznidazole, as well as evaluates their trypanocidal activity. In this work, reactions to modify the PEG 4000 polymer and the subsequent incorporation of the benznidazole were made. The nuclear magnetic resonance (NMR) analysis confirmed the efficiency in modifying the PEG chains. The morphology of polymeric films was observed by atomic force microscopy (AFM) and showed considerable changes on the film organization. The acetylation of PEG favored the stability of the system and an increase in the zeta potential from -14.83 to -25.54 mV was observed. Although encapsulation efficiency values between 30.14 and 39.48% were found, the enhanced benznidazole dissolution profile by microparticles enables the use of lower drug concentrations. This fact can be proven by the increased trypanocidal effect of benznidazole when encapsulated in BP3 microparticles. Finally, the high selectivity of the formulations for trypanocidal action guarantees their safety as an alternative for the treatment of the Chagas disease.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of the Brazilian Chemical Society-
dc.rightsAcesso Abertopt_BR
dc.subjectBenznidazolept_BR
dc.subjectChagas diseasept_BR
dc.subjectCytotoxicitypt_BR
dc.subjectMicroparticlespt_BR
dc.subjectPolymerpt_BR
dc.subject.otherDoença de Chagaspt_BR
dc.subject.otherPolímerospt_BR
dc.titleTrypanocidal activity and increased solubility of benznidazole incorporated in PEG 4000 and its derivativespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://dx.doi.org/10.21577/0103-5053.20210017pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2408-3448pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6002-857Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1807-971Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0464-4754pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8523-2155pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0644-9197pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0888-5072pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6426-7113pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8904-6990pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6112-5574pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7033-7686pt_BR
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