1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56083
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorAgnaldo Lopes Silva-filhopt_BR
dc.creatorErika Becker s Xavierpt_BR
dc.creatorEduardo Batista Cândidopt_BR
dc.creatorRicardo Macarencopt_BR
dc.creatorMárcia c f Ferreirapt_BR
dc.creatorMarcelo Antônio Pascoal Xavierpt_BR
dc.creatorRayara a m Macielpt_BR
dc.creatorPaula Vieira Teixeira Vidigalpt_BR
dc.date.accessioned2023-07-11T20:35:44Z-
dc.date.available2023-07-11T20:35:44Z-
dc.date.issued2016-08-02-
dc.citation.volume102pt_BR
dc.citation.issue5pt_BR
dc.citation.spage488pt_BR
dc.citation.epage495pt_BR
dc.identifier.doiDOI: 10.5301/tj.5000528pt_BR
dc.identifier.issn03008916pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56083-
dc.description.resumoPurpose: To evaluate the concordance among the available histologic classifications for endometrial adenocarcinoma using interobserver and intraobserver agreement as well as the association of tumor histologic degree in the above mentioned classifications with cellular proliferation measured by Ki-67.Methods: Seventy women who underwent surgical treatment of endometrial adenocarcinoma with histologic confirmation of endometrioid type were included in the study. Two experienced pathologists randomly analyzed the slides in 3 distinct timeframes with a maximum of 25 slides/timeframe. Tumor slides were classified according to the degree of differentiation using 4 different classifications: International Federation of Gynecology and Obstetrics (FIGO), modified FIGO, Lax, and Alkushi. Results: Intraobserver agreement was reasonable for classification of FIGO (k 0.469 and 0.538), very good for modi fied FIGO (k 0.661 and 0.768), moderate for Lax classification (k 0.496 and 0.466), and moderate/good for Alkushi classification (k 0.528 and 0.736). Interobserver concordance was regular for FIGO classification (k = 0.271 and 0.343), good/moderate for modified FIGO classification (k = 0.661 and 0.522, respectively), regular/moderate for Lax classification (k = 0.258 and 0.465, respectively), and regular for Alkushi classification (k = 0.283 and 0.402).Conclusions: The prognostic value of histologic grading in endometrial carcinoma and its importance for a successful therapeutic plan have been documented repeatedly, but the best grading system, in terms of prognostication, reproducibility, ease of use, and universality (e.g., applicability to all tumor cell types), has not been unequivocally defined.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofTumori Journal-
dc.rightsAcesso Restritopt_BR
dc.subjectDifferential diagnosispt_BR
dc.subjectEndometrial carcinomapt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subject.otherDiagnóstico Diferencialpt_BR
dc.subject.otherNeoplasias do Endométriopt_BR
dc.subject.otherImuno-Histoquímicapt_BR
dc.titleComparative study of different histologic classifications in the degree of differentiation in endometrial adenocarcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.sagepub.com/doi/10.5301/tj.5000528pt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.