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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56301
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Campo DCValorIdioma
dc.creatorTauyne Menegaldo Pinheiropt_BR
dc.creatorBárbara Aparecida Chavespt_BR
dc.creatorMayara Marques Carneiro da Silvapt_BR
dc.creatorIzabella Cristina Andrade Batistapt_BR
dc.creatorMichelle Premazzi Papapt_BR
dc.creatorLana Monteiro Meurenpt_BR
dc.creatorCarolina Gonçalves de Oliveira Lucaspt_BR
dc.creatorFlavio Lemos Matassolipt_BR
dc.creatorLaura Helena Vega Gonzales Gilpt_BR
dc.creatorAdriana Bozzipt_BR
dc.creatorCarlos Eduardo Calzavara Silvapt_BR
dc.creatorMânlio Tasso de Oliveira Motapt_BR
dc.creatorLuciana Barros de Arrudapt_BR
dc.creatorDanielle da Glória de Souzapt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorNikos Vasilakispt_BR
dc.creatorMaurício Lacerda Nogueirapt_BR
dc.creatorAripuanã Sakurada Aranha Watanabept_BR
dc.creatorJoice Matos Biselli Péricopt_BR
dc.creatorBetânia Paiva Drumondpt_BR
dc.creatorMilene Rocha Ribeiropt_BR
dc.creatorDanila Vedovellopt_BR
dc.creatorJoão Pessoa Araújopt_BR
dc.creatorPaulo Filemon Paolucci Pimentapt_BR
dc.date.accessioned2023-07-14T20:36:33Z-
dc.date.available2023-07-14T20:36:33Z-
dc.date.issued2018-
dc.citation.volume12pt_BR
dc.citation.issue5pt_BR
dc.citation.spage1pt_BR
dc.citation.epage25pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0006525pt_BR
dc.identifier.issn1935-2735pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56301-
dc.description.resumoThe dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLOS Neglected Tropical Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDengue virus (DENV)pt_BR
dc.subjectSão José do Rio Preto, Brazilpt_BR
dc.subjectGenotype Vpt_BR
dc.subjectEpidemicspt_BR
dc.subject.otherDengue - Epidemiologiapt_BR
dc.subject.otherSão Jose do Rio Preto, Região de (SP)pt_BR
dc.titleViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006525pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-9879pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1957-666Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8198-6016pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8242-5584pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1406-6401pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3432-0769pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1102-2419pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0875-2269pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5105-9537pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4177-7532pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8585-8206pt_BR
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