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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56324
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Campo DCValorIdioma
dc.creatorFranciel Batista Felixpt_BR
dc.creatorGabriel Henrique Campolina Silvapt_BR
dc.creatorFrederico Marianetti Sorianipt_BR
dc.creatorLirlândia Pires Sousapt_BR
dc.creatorRenata Grespanpt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorVanessa Pinhopt_BR
dc.creatorJuliana Priscila Vagopt_BR
dc.creatorDébora de Oliveira Fernandespt_BR
dc.creatorDébora Gonzaga Martinspt_BR
dc.creatorIsabella Zaidan Moreirapt_BR
dc.creatorWalyson Coelho Costapt_BR
dc.creatorJessica Maria Dantas Araújopt_BR
dc.creatorCelso Martins Queiroz Juniorpt_BR
dc.creatorWilliam Antonio Gonçalvespt_BR
dc.date.accessioned2023-07-14T22:29:41Z-
dc.date.available2023-07-14T22:29:41Z-
dc.date.issued2021-
dc.citation.volume12pt_BR
dc.citation.spage1pt_BR
dc.citation.epage17pt_BR
dc.identifier.doihttps://doi.org/10.3389/fphar.2021.662308pt_BR
dc.identifier.issn1663-9812pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56324-
dc.description.resumoBiochaninA(BCA)isanaturalorganiccompoundoftheclassofphytochemicalsknownas flavonoidsandisoflavonesubclasspredominantlyfoundinredclover(Trifoliumpratense).It has anti-inflammatory activity and some pro-resolving actions, such as neutrophil apoptosis. However, the effect of BCA in the resolution of inflammation is still poorly understood. In this study, we investigated the effects of BCA on the neutrophilic inflammatory response and its resolution in a model of antigen-induced arthritis. Male wild-type BALB/c mice were treated with BCA at the peak of the inflammatory process (12h). BCA decreased the accumulation of migrated neutrophils, and this effect was associated with reduction of myeloperoxidase activity, IL-1β and CXCL1 levels, and the histological score in periarticular tissues. Joint dysfunction, as seen by mechanical hypernociception, was improved by treatment with BCA. The resolution interval (Ri) was also quantified, defining profiles of acute inflammatory parameters that include the amplitude and duration of the inflammatory response monitored by the neutrophil infiltration. BCA treatment shortened Ri from ∼23h observed in vehicle-treated mice to ∼5.5h, associated with an increase in apoptotic events and efferocytosis, both key steps for the resolution of inflammation. These effects of BCA were prevented by H89, an inhibitor of protein kinase A (PKA) and G15, a selective G protein–coupled receptor 30 (GPR30)antagonist.Inlinewiththeinvivodata,BCAalsoincreasedtheefferocyticabilityof murine bone marrow–derived macrophages. Collectively, these data indicate for the first time that BCA resolves neutrophilic inflammation acting in key steps of the resolution of inflammation, requiring activation of GPR30 and via stimulation of cAMP-dependent signaling.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Pharmacologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBiochanin A (PubChem CID 5280373)pt_BR
dc.subjectArthritispt_BR
dc.subjectApoptosispt_BR
dc.subjectEfferocytosispt_BR
dc.subjectResolution of inflammationpt_BR
dc.subject.otherArtritept_BR
dc.subject.otherApoptosept_BR
dc.subject.otherInflamaçãopt_BR
dc.titleBiochanin A Regulates Key Steps of Inflammation Resolution in a Model of Antigen-Induced Arthritis via GPR30/PKA-Dependent Mechanismpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fphar.2021.662308/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2372-2781pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4473-3340pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4720-6746pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1042-9762pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3644-7632pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1038-2324pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8188-3738pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8666-6342pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7853-3809pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9434-8814pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4178-0387pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4041-6441pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7884-7709pt_BR
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