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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56341
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Campo DCValorIdioma
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorGabriela Neves Vazpt_BR
dc.creatorNatalia Pessoa Rochapt_BR
dc.creatorRodrigo Machado-vieirapt_BR
dc.creatorMarcio Rogerio Diniz Venturapt_BR
dc.creatorRodrigo b. Huguetpt_BR
dc.creatorMoises e. Bauerpt_BR
dc.creatorMichael Berkpt_BR
dc.creatorAntônio l. Teixeirapt_BR
dc.date.accessioned2023-07-14T22:56:06Z-
dc.date.available2023-07-14T22:56:06Z-
dc.date.issued2017-05-09-
dc.citation.volume15pt_BR
dc.citation.issue3pt_BR
dc.citation.spage269pt_BR
dc.citation.epage275pt_BR
dc.identifier.doihttps://doi.org/10.9758/cpn.2017.15.3.269pt_BR
dc.identifier.issn17381088pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56341-
dc.description.resumoObjective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the HamiltonDepression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Psychopharmacology and Neuroscience-
dc.rightsAcesso Abertopt_BR
dc.subjectBipolar disorderpt_BR
dc.subjectTWEAKpt_BR
dc.subjectsTNFRpt_BR
dc.subjectTRAILpt_BR
dc.subject.otherTranstorno Bipolarpt_BR
dc.subject.otherReceptor de TWEAKpt_BR
dc.subject.otherReceptores do Ligante Indutor de Apoptose Relacionado a TNFpt_BR
dc.titlePlasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorderpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2017.15.3.269pt_BR
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