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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56358
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dc.creatorÁtila Duque Rossipt_BR
dc.creatorHugo José Alvespt_BR
dc.creatorHelena Toledo Scheidpt_BR
dc.creatorDébora Souza Faffept_BR
dc.creatorRafael Mello Galliezpt_BR
dc.creatorRenata Eliane de Ávilapt_BR
dc.creatorGustavo Gomes Resendept_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorOrlando da Costa Ferreira Júniorpt_BR
dc.creatorTerezinha Marta Castineiraspt_BR
dc.creatorRenan Pedra Souzapt_BR
dc.creatorJoão Locke Ferreira de Araújopt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorShana Priscila Coutinho Barrosopt_BR
dc.creatorCynthia Chester Cardosopt_BR
dc.creatorTailah Bernardo de Almeidapt_BR
dc.creatorMarcelo Ribeiro-alvespt_BR
dc.creatorCamila de Almeida Velozopt_BR
dc.creatorJéssica Maciel de Almeidapt_BR
dc.creatorIsabela de Carvalho Leitãopt_BR
dc.creatorSâmila Natiane Ferreirapt_BR
dc.creatorJéssica da Silva Oliveirapt_BR
dc.date.accessioned2023-07-15T00:20:58Z-
dc.date.available2023-07-15T00:20:58Z-
dc.date.issued2021-
dc.citation.volume11pt_BR
dc.citation.issue9658pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-021-88944-8pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56358-
dc.description.resumoACE2 and TMPRSS2 are key players on SARS-CoV-2 entry into host cells. However, it is still unclear whether expression levels of these factors could reflect disease severity. Here, a case–control study was conducted with 213 SARS-CoV-2 positive individuals where cases were defined as COVID-19 patients with respiratory distress requiring oxygen support (N = 38) and controls were those with mild to moderate symptoms of the disease who did not need oxygen therapy along the entire clinical course (N = 175). ACE2 and TMPRSS2 mRNA levels were evaluated in nasopharyngeal swab samples by RT-qPCR and logistic regression analyzes were applied to estimate associations with respiratory outcomes. ACE2 and TMPRSS2 levels positively correlated with age, which was also strongly associated with respiratory distress. Increased nasopharyngeal ACE2 levels showed a protective effect against this outcome (adjOR = 0.30; 95% CI 0.09–0.91), while TMPRSS2/ACE2 ratio was associated with risk (adjOR = 4.28; 95% CI 1.36–13.48). On stepwise regression, TMPRSS2/ACE2 ratio outperformed ACE2 to model COVID-19 severity. When nasopharyngeal swabs were compared to bronchoalveolar lavages in an independent cohort of COVID-19 patients under mechanical ventilation, similar expression levels of these genes were observed. These data suggest nasopharyngeal TMPRSS2/ACE2 as a promising candidate for further prediction models on COVID-19.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCOVID-19pt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectRespiratory distresspt_BR
dc.subject.otherCOVID-19pt_BR
dc.subject.otherDesconforto respiratoriopt_BR
dc.titleAssociation between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distresspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41598-021-88944-8pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6235-8807pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1450-0148pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5795-429Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5255-5938pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0348-8374pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6566-9280pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1970-8936pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4746-6049pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9479-4432pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8338-8351pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7890-9255pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3695-4434pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8663-3364pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0105-1312pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0752-120Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7919-612Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2591-1818pt_BR
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