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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56414
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Campo DCValorIdioma
dc.creatorSarah Hillpt_BR
dc.creatorAna Luísa Micolo Cândidopt_BR
dc.creatorFilipa Vazpt_BR
dc.creatorCruz dos Santos Sebastiãopt_BR
dc.creatorChieh-Hsi Wupt_BR
dc.creatorMoritz U. G. Kraemerpt_BR
dc.creatorAdriana Melopt_BR
dc.creatorBruno Luiz Fonseca Schamber-Reispt_BR
dc.creatorGirlene S. de Azevedopt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorLuiza Higapt_BR
dc.creatorJocelyne Vasconcelospt_BR
dc.creatorCarina Clementept_BR
dc.creatorSara Pereira da Silvapt_BR
dc.creatorDarlan da Silva Candidopt_BR
dc.creatorIngra Claropt_BR
dc.creatorDomingos Quibucopt_BR
dc.creatorCristóvão Domingospt_BR
dc.creatorBárbara Pocongopt_BR
dc.creatorAlexander Wattspt_BR
dc.creatorKamran Khanpt_BR
dc.creatorLuiz Carlos Junior Alcantarapt_BR
dc.creatorZoraima Netopt_BR
dc.creatorEster C. Sabinopt_BR
dc.creatorEve Lackritzpt_BR
dc.creatorOliver Pybuspt_BR
dc.creatorMaria João Alvespt_BR
dc.creatorJoana Afonsopt_BR
dc.creatorNuno R. Fariapt_BR
dc.creatorDomingos Jandondopt_BR
dc.creatorLíbia Zé-zépt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorJoilson Xavierpt_BR
dc.creatorJulien Thézépt_BR
dc.creatorMarinela Mirandelapt_BR
dc.date.accessioned2023-07-17T18:02:10Z-
dc.date.available2023-07-17T18:02:10Z-
dc.date.issued2019-
dc.citation.volume19pt_BR
dc.citation.issue10pt_BR
dc.citation.spage1138pt_BR
dc.citation.epage1147pt_BR
dc.identifier.doihttps://doi.org/10.1016/S1473-3099(19)30293-2pt_BR
dc.identifier.issn1473-3099pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56414-
dc.description.resumoBackground Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-time reverse transcription PCR by the Instituto Nacional de Investigação em Saúde (Ministry of Health, Luanda, Angola). To identify further samples positive for Zika virus and appropriate for genomic sequencing, we also tested samples from a 2017 study of people with HIV in Luanda. Portable sequencing was used to generate Angolan Zika virus genome sequences from three people positive for Zika virus infection by real-time reverse transcription PCR, including one neonate with microcephaly. Genetic and mobility data were analysed to investigate the date of introduction and geographical origin of Zika virus in Angola. Brain CT and MRI, and serological assays were done on a child with microcephaly to confirm microcephaly and assess previous Zika virus infection. Findings Serum samples from 54 people with suspected acute Zika virus infection, 76 infants with suspected microcephaly, 24 mothers of infants with suspected microcephaly, 336 patients with suspected dengue virus or chikungunya virus infection, and 349 samples from the HIV study were tested by real-time reverse transcription PCR. Four cases identified between December, 2016, and June, 2017, tested positive for Zika virus. Analyses of viral genomic and human mobility data suggest that Zika virus was probably introduced to Angola from Brazil between July, 2015, and June, 2016. This introduction probably initiated local circulation of Zika virus in Angola that continued until at least June, 2017. The infant with microcephaly in whom CT and MRI were done had brain abnormalities consistent with congenital Zika syndrome and serological evidence for Zika virus infection. Interpretation Our analyses show that autochthonous transmission of the Asian lineage of Zika virus has taken place in Africa. Zika virus surveillance and surveillance of associated cases of microcephaly throughout the continent is crucial. Funding Royal Society, Wellcome Trust, Global Challenges Research Fund (UK Research and Innovation), Africa Oxford, John Fell Fund, Oxford Martin School, European Research Council, Departamento de Ciência e Tecnologia/Ministério da Saúde/National Council for Scientific and Technological Development, and Ministério da Educação/Coordenação de Aperfeicoamento de Pessoal de Nível Superior.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Lancet: Infectious Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectZikapt_BR
dc.subjectAfricapt_BR
dc.subject.otherVírus da Zikapt_BR
dc.subject.otherÁfricapt_BR
dc.titleEmergence of the Asian lineage of Zika virus in Angola: an outbreak investigationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1473309919302932?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2995-2596pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1232-0119pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9386-725Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0814-6931pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7640-1463pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2622-534Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7318-693Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5080-3130pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8637-2910pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3480-582Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0852-0492pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5397-7291pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8797-2667pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6943-7890pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7258-1439pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3916-2018pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8188-9494pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8847-4136pt_BR
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