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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56419
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Campo DCValorIdioma
dc.creatorFelipe Gomes Navecapt_BR
dc.creatorJosé Lourençopt_BR
dc.creatorMauricio Santillanapt_BR
dc.creatorMoritz U. G. Kraemerpt_BR
dc.creatorJosh Quickpt_BR
dc.creatorSarah C. Hillpt_BR
dc.creator‪Julien Thézé‬pt_BR
dc.creatorRodrigo Dias de Oliveira Carvalhopt_BR
dc.creatorVasco Ariston de Carvalho Azevedopt_BR
dc.creatorFlavia Cristina da Silva Sallespt_BR
dc.creatorMárcio Roberto Teixeira Nunespt_BR
dc.creatorIngra Claropt_BR
dc.creatorPoliana da Silva Lemospt_BR
dc.creatorDarlan da Silva Candidopt_BR
dc.creatorGlauco de Carvalho Pereirapt_BR
dc.creatorMarluce Aparecida Assunção Oliveirapt_BR
dc.creatorCátia Alexandra Ribeiro Menesespt_BR
dc.creatorRodrigo Melo Maitopt_BR
dc.creatorClaudeth Rocha Santa Brígida Cunhapt_BR
dc.creatorDaniela Palha de Sousa Campospt_BR
dc.creatorMarcia da Costa Castilhopt_BR
dc.creatorThalita Caroline da Silva Siqueirapt_BR
dc.creatorMarta Giovanettipt_BR
dc.creatorTiza Matos Terrapt_BR
dc.creatorCarlos Campelo de Albuquerquept_BR
dc.creatorLaura Nogueira da Cruzpt_BR
dc.creatorAndré Luis de Abreupt_BR
dc.creatorDivino Valerio Martinspt_BR
dc.creatorDaniele Silva de Moraes Vanlume Simoespt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorSérgio Luiz Bessa Luzpt_BR
dc.creatorNicholas Lomanpt_BR
dc.creatorOliver G. Pybuspt_BR
dc.creatorJaqueline Goes de Jesuspt_BR
dc.creatorEster C. Sabinopt_BR
dc.creatorOsnei Okumotopt_BR
dc.creatorLuiz Carlos Junior Alcantarapt_BR
dc.creatorNuno Rodrigues Fariapt_BR
dc.creatorJoilson Xavierpt_BR
dc.creatorFelipe Campos de Melo Ianipt_BR
dc.creatorValdinete Alves do Nascimentopt_BR
dc.creatorVictor Costa de Souzapt_BR
dc.creatorPaola Paz Silveirapt_BR
dc.date.accessioned2023-07-17T18:04:21Z-
dc.date.available2023-07-17T18:04:21Z-
dc.date.issued2019-
dc.citation.volume13pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1pt_BR
dc.citation.epage21pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0007065pt_BR
dc.identifier.issn1935-2735pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56419-
dc.description.resumoBackground Since its first detection in the Caribbean in late 2013, chikungunya virus (CHIKV) has affected 51 countries in the Americas. The CHIKV epidemic in the Americas was caused by the CHIKV-Asian genotype. In August 2014, local transmission of the CHIKV-Asian genotype was detected in the Brazilian Amazon region. However, a distinct lineage, the CHIKV-East-Central-South-America (ECSA)-genotype, was detected nearly simultaneously in Feira de Santana, Bahia state, northeast Brazil. The genomic diversity and the dynamics of CHIKV in the Brazilian Amazon region remains poorly understood despite its importance to better understand the epidemiological spread and public health impact of CHIKV in the country. Methodology/Principal findings We report a large CHIKV outbreak (5,928 notified cases between August 2014 and August 2018) in Boa vista municipality, capital city of Roraima’s state, located in the Brazilian Amazon region. We generated 20 novel CHIKV-ECSA genomes from the Brazilian Amazon region using MinION portable genome sequencing. Phylogenetic analyses revealed that despite an early introduction of the Asian genotype in 2015 in Roraima, the large CHIKV outbreak in 2017 in Boa Vista was caused by an ECSA-lineage most likely introduced from northeastern Brazil. Epidemiological analyses suggest a basic reproductive number of R0 of 1.66, which translates in an estimated 39 (95% CI: 36 to 45) % of Roraima’s population infected with CHIKV-ECSA. Finally, we find a strong association between Google search activity and the local laboratory-confirmed CHIKV cases in Roraima. Conclusions/Significance This study highlights the potential of combining traditional surveillance with portable genome sequencing technologies and digital epidemiology to inform public health surveillance in the Amazon region. Our data reveal a large CHIKV-ECSA outbreak in Boa Vista, limited potential for future CHIKV outbreaks, and indicate a replacement of the Asian genotype by the ECSA genotype in the Amazon region. Author summary Until the end of 2017, Brazil notified the highest number of infections caused by chikungunya virus (CHIKV) in the Americas. We investigated a large CHIKV outbreak in Boa vista municipality in the Brazilian Amazon region. Rapid portable genome sequencing of 20 novel isolates and subsequent genetic analysis revealed that ECSA lineage was introduced from northeastern Brazil to Roraima around July 2016. Epidemiological analyses suggest a basic reproductive number of R0 of 1.66, which suggests that approximately 39% of Roraima’s population was infected with CHIKV-ECSA. Given the dominance of the CHIKV-Asian genotype in the Americas, our data highlights the rapid spread of a less understood and poorly characterized CHIKV-ECSA genotype in Brazil. Investigations on potential associations between public health impact of CHIKV and genetic diversity of circulating strains are warranted to better evaluate its impact in Brazil and beyond.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLOS Neglected Tropical Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBrazilian Amazonpt_BR
dc.subjectChikungunya viruspt_BR
dc.subjectGenomicpt_BR
dc.subject.otherAmazôniapt_BR
dc.subject.otherChikungunyapt_BR
dc.subject.otherGenômicapt_BR
dc.titleGenomic, epidemiological and digital surveillance of Chikungunya virus in the Brazilian Amazonpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007065pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2888-1060pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-9318-2581pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4206-418Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8637-2910pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1271-8549pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5080-3130pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1651-7066pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6344-2143pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0007-9624-6222pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0009-0769-3827pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7411-7445pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2657-4400pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5887-7372pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9843-8988pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8797-2667pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3629-8529pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7786-4718pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3669-2219pt_BR
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