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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56456
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dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorNatalia Pessoa Rochapt_BR
dc.creatorGokay Alpakpt_BR
dc.creatorErica Leandro Marciano Vieirapt_BR
dc.creatorRodrigo Barreto Huguetpt_BR
dc.creatorFabio Lopes Rochapt_BR
dc.creatorBreno Satler de Oliveira Dinizpt_BR
dc.creatorAntonio Lucio Teixeirapt_BR
dc.date.accessioned2023-07-17T19:09:02Z-
dc.date.available2023-07-17T19:09:02Z-
dc.date.issued2017-08-09-
dc.citation.volume95pt_BR
dc.citation.issue2017pt_BR
dc.citation.spage80pt_BR
dc.citation.epage88pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jpsychires.2017.08.007pt_BR
dc.identifier.issn00223956pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56456-
dc.description.resumoAim: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore,this study was designed to evaluate plasma levels of Klotho in BD patients and controls. Methods: Forty patients with type 1 BD and 30 controls were enrolled in this study. After clinical evaluation, peripheral blood samples were drawn and plasma levels of Klotho were measured using enzyme-linked immunosorbent assay. Results: Patients with BD and controls presented similar age and sex distribution. The mean ± SD length of illness was 24.00 ± 12.75 years. BD patients presented increased frequency of clinical comorbidities in comparison with controls, mainly arterial hypertension, diabetes mellitus, and hypothyroidism. Both patients with BD in remission and in mania exhibited increased plasma levels of Klotho in comparison with controls. There was no significant difference between patients in mania and patients in remission regarding the levels of Klotho. Conclusion: Klotho-related pathway is altered in BD. Contrary to our original hypothesis, our sample of patients with BD presented increased plasma levels of Klotho in comparison with controls. Elevated levels of Klotho in long-term BD patients may be associated with the disorder progression. Further studies are needed to better understand the role of Klotho in BD and other mood disorderspt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Psychiatric Research-
dc.rightsAcesso Restritopt_BR
dc.subjectAgingpt_BR
dc.subjectBipolar disorderpt_BR
dc.subjectInflammationpt_BR
dc.subjectKlothopt_BR
dc.subjectMood disorderpt_BR
dc.subjectMood disorderpt_BR
dc.subject.otherEnvelhecimentopt_BR
dc.subject.otherTranstorno Bipolarpt_BR
dc.subject.otherProteínas Klothopt_BR
dc.subject.otherTranstornos do Humorpt_BR
dc.titleKlotho dysfunction: a pathway linking the aging process to bipolar disorder?pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0022395617304351pt_BR
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