1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56472
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorSarah C. Hillpt_BR
dc.creatorFlavia Cristina da Silva Salespt_BR
dc.creatorIray M. Roccopt_BR
dc.creatorAdriana Yumi Maedapt_BR
dc.creatorFernanda G. S. Vasamipt_BR
dc.creatorLouis du Plessispt_BR
dc.creatorPaola P. Silveirapt_BR
dc.creatorJaqueline G. de Jesuspt_BR
dc.creatorJoshua Quickpt_BR
dc.creatorNatália Coelho Couto de Azevedo Fernandespt_BR
dc.creatorJuliana M. Guerrapt_BR
dc.creatorRenato de Souzapt_BR
dc.creatorRodrigo A. Réssiopt_BR
dc.creatorMarta Giovanettipt_BR
dc.creatorLuiz C. J. Alcantarapt_BR
dc.creatorCinthya dos Santos Cirqueira Borgespt_BR
dc.creatorJosué Díaz-Delgadopt_BR
dc.creatorFernando Luiz de Lima Macedopt_BR
dc.creatorMaria do Carmo Timenetskypt_BR
dc.creatorRegiane de Paulapt_BR
dc.creatorRoberta Spinolapt_BR
dc.creatorJuliana Telles de Deuspt_BR
dc.creatorJulien Thézépt_BR
dc.creatorLuís Filipe Muccipt_BR
dc.creatorRosa Maria Tubakipt_BR
dc.creatorRegiane Maria Tironi de Menezespt_BR
dc.creatorPatricia Locosque Ramospt_BR
dc.creatorAndre L. de Abreupt_BR
dc.creatorLaura N. Cruzpt_BR
dc.creatorNick Lomanpt_BR
dc.creatorSimon Dellicourpt_BR
dc.creatorOliver G. Pybuspt_BR
dc.creatorEster C. Sabinopt_BR
dc.creatorIngra Claropt_BR
dc.creatorNuno R. Fariapt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorLeandro Abadept_BR
dc.creatorFabiana dos Santospt_BR
dc.creatorMariana Sequetin Cunhapt_BR
dc.creatorJuliana da Silva Nogueirapt_BR
dc.date.accessioned2023-07-17T19:29:28Z-
dc.date.available2023-07-17T19:29:28Z-
dc.date.issued2020-
dc.citation.volume16pt_BR
dc.citation.issue8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage18pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1008699pt_BR
dc.identifier.issn1553-7374pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56472-
dc.description.resumoSão Paulo, a densely inhabited state in southeast Brazil that contains the fourth most populated city in the world, recently experienced its largest yellow fever virus (YFV) outbreak in decades. YFV does not normally circulate extensively in São Paulo, so most people were unvaccinated when the outbreak began. Surveillance in non-human primates (NHPs) is important for determining the magnitude and geographic extent of an epizootic, thereby helping to evaluate the risk of YFV spillover to humans. Data from infected NHPs can give more accurate insights into YFV spread than when using data from human cases alone. To contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in São Paulo, we generated and analysed virus genomic data and epizootic case data from NHPs in São Paulo. We report the occurrence of three spatiotemporally distinct phases of the outbreak in São Paulo prior to February 2018. We generated 51 new virus genomes from YFV positive cases identified in 23 different municipalities in São Paulo, mostly sampled from NHPs between October 2016 and January 2018. Although we observe substantial heterogeneity in lineage dispersal velocities between phylogenetic branches, continuous phylogeographic analyses of generated YFV genomes suggest that YFV lineages spread in São Paulo at a mean rate of approximately 1km per day during all phases of the outbreak. Viral lineages from the first epizootic phase in northern São Paulo subsequently dispersed towards the south of the state to cause the second and third epizootic phases there. This alters our understanding of how YFV was introduced into the densely populated south of São Paulo state. Our results shed light on the sylvatic transmission of YFV in highly fragmented forested regions in São Paulo state and highlight the importance of continued surveillance of zoonotic pathogens in sentinel species.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLOS Pathogenspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSão Paulo, Brazilpt_BR
dc.subjectYellow fever virus (YFV)pt_BR
dc.subject.otherFebre amarelapt_BR
dc.subject.otherBrasil - São Paulopt_BR
dc.titleGenomic Surveillance of Yellow Fever Virus Epizootic in São Paulo, Brazil, 2016 – 2018pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008699pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-9048-0030pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8793-5479pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2195-9707pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-3719-5505pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1216-5446pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2097-0429pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8317-0539pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1617-7340pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-8188-9494pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-7766-7597pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9688-5266pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1778-437Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2726-4949pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1751-4537pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8903-604Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3059-0270pt_BR
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