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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56479
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dc.creatorSoniza Vieira Alves Leonpt_BR
dc.creatorLuiza Mendonça Higapt_BR
dc.creatorAna Paula de Campos Guimarãespt_BR
dc.creatorMariane Talon de Menezespt_BR
dc.creatorMarcelo Calado de Paula Tôrrespt_BR
dc.creatorRichard Araújo Maiapt_BR
dc.creatorBruno Miceli Gonzalez Nogueirapt_BR
dc.creatorLaise Carolina Françapt_BR
dc.creatorMarcos Martins da Silvapt_BR
dc.creatorChristian Naurathpt_BR
dc.creatorCristina dos Santos Ferreirapt_BR
dc.creatorAline Saraiva da Silva Correiapt_BR
dc.creatorClaudia Cristina Ferreira Vasconcelospt_BR
dc.creatorOrlando Costa Ferreirapt_BR
dc.creatorCynthia Chester Cardosopt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorAna Tereza Ribeiro de Vasconcelospt_BR
dc.creatorAlice Laschuk Herlingerpt_BR
dc.creatorFabrícia Lima Fontes Dantaspt_BR
dc.creatorFernanda Rueda Lopespt_BR
dc.creatorRonaldo da Silva Franciscopt_BR
dc.creatorJoão Paulo da Costa Gonçalvespt_BR
dc.creatorAmanda Dutra de Araújopt_BR
dc.creatorCláudia Cecília da Silva Rêgopt_BR
dc.creatorAlexandra Lehmkuhl Gerberpt_BR
dc.creatorAmilcar Tanuript_BR
dc.date.accessioned2023-07-17T19:59:36Z-
dc.date.available2023-07-17T19:59:36Z-
dc.date.issued2021-
dc.citation.volume12pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.3389/fgene.2021.639364pt_BR
dc.identifier.issn1664-8021pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56479-
dc.description.resumoChikungunya virus (CHIKV) is a re-emergent arbovirus that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia, although <1% of cases develop severe neurological manifestations such as inflammatory demyelinatingdiseases(IDD)ofthecentralnervoussystem(CNS)likeacutedisseminated encephalomyelitis (ADEM) and extensive transverse myelitis. Genetic factors associated with host response and disease severity are still poorly understood. In this study, we performed whole-exome sequencing (WES) to identify HLA alleles, genes and cellular pathways associated with CNS IDD clinical phenotype outcomes following CHIKV infection. The cohort includes 345 patients of which 160 were confirmed for CHIKV. Six cases presented neurological manifestation mimetizing CNS IDD. WES data analysis was performed for 12 patients, including the CNS IDD cases and 6 CHIKV patients without any neurological manifestation. We identified 29 candidate genes harboring rare, pathogenic, or probably pathogenic variants in all exomes analyzed. HLA alleles were also determined and patients who developed CNS IDD shared a common signature with diseases such as Multiple sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD). When these genes were included in Gene Ontology analyses, pathways associated with CNS IDD syndromes were retrieved, suggesting that CHIKV-induced CNSoutcomesmayshareageneticbackgroundwithotherneurologicaldisorders.Toour knowledge, this study was the first genome-wide investigation of genetic risk factors for CNS phenotypes in CHIKV infection. Our data suggest thatHLA-DRB1 allelesassociated with demyelinating diseases may also confer risk of CNS IDD outcomes in patients with CHIKV infection.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Geneticspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectWhole exome sequencept_BR
dc.subjectChikungunyapt_BR
dc.subjectPathogenic variantspt_BR
dc.subjectHLA allelespt_BR
dc.subjectInflammatory demyelinating diseasespt_BR
dc.subjectNeurological manifestations in viral infectionpt_BR
dc.subjectAcute disseminated encephalomyelitispt_BR
dc.subjectMyelitispt_BR
dc.subject.otherChikungunyapt_BR
dc.subject.otherBacterias patogenicaspt_BR
dc.subject.otherDoenças inflamatóriaspt_BR
dc.subject.otherEncefalomielitept_BR
dc.titleExome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: the Tip of the Icebergpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fgene.2021.639364/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1538-6730pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6587-3871pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7931-3963pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8851-7845pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1770-607Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5870-5068pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9096-5751pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4632-2086pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7660-7058pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5201-0927pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3782-8624pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5724-6106pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0570-750Xpt_BR
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