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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56492
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Campo DCValorIdioma
dc.creatorNatalia Pessoa Rochapt_BR
dc.creatorFrankcinéia Assispt_BR
dc.creatorPaula Luciana Scalzopt_BR
dc.creatorÉrica Leandro Marciano Vieirapt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorMariana Soares de Souzapt_BR
dc.creatorPaulo Pereira Christopt_BR
dc.creatorHelton José Reispt_BR
dc.creatorAntonio Lucio Teixeira Juniorpt_BR
dc.date.accessioned2023-07-17T20:12:27Z-
dc.date.available2023-07-17T20:12:27Z-
dc.date.issued2017-02-07-
dc.citation.volume55pt_BR
dc.citation.issue2pt_BR
dc.citation.spage1488pt_BR
dc.citation.epage1497pt_BR
dc.identifier.doihttps://doi.org/10.1007/s12035-017-0404-ypt_BR
dc.identifier.issn08937648pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56492-
dc.description.resumoAbstract Parkinson’s disease (PD) is the second most com mon neurodegenerative disease. The cause of neurodegeneration in PD is not completely understood, and evidence has shown that inflammatory/immune changes may be involved in PD pathophysiology. Herein, we aimed to determine the profile of the peripheral immune system in patients with PD in comparison with controls. Forty patients with PD and 25 age- and gender-matched controls were enrolled in this study. From these, 23 PD patients and 21 controls were included in the immunophenotyping analyses. Peripheral blood was drawn on the same day of the clinical assessment and submitted to plasma separation for enzyme-linked immunosorbent assay or cytometric bead array. Immunophenotyping analyses of the peripheral blood were performed by flow cytometry. We found that patients with PD presented peripheral immune changes evidenced by decreased percentage of T lymphocytes (CD3+ cells), especially activated T lymphocytes (CD4+CD25+ cells), when compared with controls. In line with these results, we also found decreased plasma levels of the cytokines IL-4, IL-6, IL-10, TNF, IFN-γ, and IL-17A in the PD group. In vitro experiments demonstrated that the produc tion of cytokines by peripheral blood mononuclear cells harvested from healthy young donors was reduced after exposure to the anti-parkinsonian drugs levodopa and pramipexole. Our data corroborate the hypothesis that immunological mechanisms are involved in PD. It is not clear whether the differences that we have found are due to adaptive mechanisms or to changes associated with PD, including pharmacological treatment, or even directly related to the disease pathophysi ology. Future studies are needed in this regard.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMolecular Neurobiology-
dc.rightsAcesso Restritopt_BR
dc.subjectParkinson’s diseasept_BR
dc.subjectImmune systempt_BR
dc.subjectInflammationpt_BR
dc.subjectImmunophenotypingpt_BR
dc.subjectLeukocytespt_BR
dc.subjectCytokinespt_BR
dc.subject.otherDoença de Parkinsonpt_BR
dc.subject.otherSistema Imunitáriopt_BR
dc.subject.otherImunofenotipagempt_BR
dc.subject.otherLeucócitospt_BR
dc.subject.otherCitocinaspt_BR
dc.titleReduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson’s Diseasept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s12035-017-0404-ypt_BR
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