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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56493
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dc.creatorÁtila Duque Rossipt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorLuiza Mendonça Higapt_BR
dc.creatorAlice Laschuk Herlingerpt_BR
dc.creatorMarcelo Ribeiro Alvespt_BR
dc.creatorMariane Talon de Menezespt_BR
dc.creatorAna Lucia Moraes Gianninipt_BR
dc.creatorCynthia Chester Cardosopt_BR
dc.creatorAndrea da Poianpt_BR
dc.creatorAmilcar Tanuript_BR
dc.date.accessioned2023-07-17T20:12:38Z-
dc.date.available2023-07-17T20:12:38Z-
dc.date.issued2021-
dc.citation.volume11pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.3389/fcimb.2021.714088pt_BR
dc.identifier.issn2235-2988pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56493-
dc.description.resumoDengue virus (DENV) is the most widespread arbovirus, responsible for a wide range of clinical manifestations, varying from self-limited illness to severe hemorrhagic fever. Dengue severity is associated with host intense proinflammatory response and monocytes have been considered one of the key cell types involved in the early steps of DENV infection and immunopathogenesis. To better understand cellular mechanisms involved in monocyte infection by DENV, we analyzed the expression levels of 754 human microRNAs in DENV-infected THP-1 cells, a human monocytic cell line. Eleven human microRNAs showed differential expression after DENV infection and gene ontology and enrichment analysis revealed biological processes potentially affected by these molecules. Five downregulated microRNAs were significantly linked to cellular response to stress, four to cell death/apoptosis, two to innate immune responses and one upregulated to vesicle mediated, TGF-β signaling, phosphatidylinositol mediated signaling, lipid metabolism process and blood coagulation.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMicroRNApt_BR
dc.subjectMonocytept_BR
dc.subjectDenguept_BR
dc.subjectGene expressionpt_BR
dc.subjectVirus-hostpt_BR
dc.subject.otherDengue - Epidemiologiapt_BR
dc.subject.otherRelação hospedeiro-viruspt_BR
dc.subject.otherMonocitospt_BR
dc.subject.otherGenetica - Expressãopt_BR
dc.titleDifferential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fcimb.2021.714088/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6235-8807pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2622-534Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7660-7058pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8663-3364pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3969-704Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0570-750Xpt_BR
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