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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/56602
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Campo DCValorIdioma
dc.creatorErika Oliveirahansenpt_BR
dc.creatorAloisio Joaquim Freitas Ribeiropt_BR
dc.creatorBernardo Mattos Vianapt_BR
dc.creatorMaria Aparecida Camargos Bicalhopt_BR
dc.creatorNatalia Silva Diaspt_BR
dc.creatorIvonne Carolina Bolaños Burgospt_BR
dc.creatorMonica Vieira Costapt_BR
dc.creatorAndréa Teixeira Carvalhopt_BR
dc.creatorAntonio Lucio Teixeirapt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorLorena Aline Valu Santospt_BR
dc.creatorDaniela Valadão Freitas Rosapt_BR
dc.date.accessioned2023-07-18T19:33:12Z-
dc.date.available2023-07-18T19:33:12Z-
dc.date.issued2021-08-31-
dc.citation.volume12pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doihttps://doi.org/10.3389/fpsyt.2021.716686pt_BR
dc.identifier.issn16640640pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56602-
dc.description.resumoBackground: Alzheimer’s disease (AD) biomarkers are of great relevance in clinical research, especially after the AT(N) framework. They enable early diagnosis, disease staging and research with new promising drugs, monitoring therapeutic response.However, the high cost and low availability of the most well-known methods limits their use in low and medium-income countries. In this context, Millipore xMap® Luminex may be a cost-effective alternative. In our study, using INNOTEST® as reference, we assess the diagnostic accuracy of Millipore xMap® and propose a cutoff point for AD. Methods: We performed lumbar puncture of seven older individuals with clinically defined AD, 17 with amnestic mild cognitive impairment (aMCI) and 11 without objective cognitive impairment-control group (CG). Cerebrospinal fluid (CSF) biomarkers concentrations for aB42, p-Tau, and t-Tau were measured by INNOTEST® and Millipore xMap®, and then the techniques were compared to assess the diagnostic accuracy of the new test and to define a cutoff. Results: INNOTEST® and Millipore xMap® measurements showed all correlations >0.8 for the same biomarker, except for t-Tau that was 0.66. Millipore xMap® measurements showed a robust accuracy for all biomarkers, with AUC higher than 0.808 (t-Tau), and the best for Aβ42 (AUC = 0.952). The most accurate cutoffs were found at 1012.98 pg/ml (Aβ42), 64.54 pg/ml (p-tau), 3251.81 pg/ml (t-tau), 3.370 (t-Tau/Aβ42), and 0.059 (p-Tau/Aβ42). Conclusion: Given its good accuracy and cost-effectiveness, Milliplex xMap® tests seems a reliable and promising tool, especially for low and middle-income countries.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Psychiatry-
dc.rightsAcesso Abertopt_BR
dc.subjectAlzheimer’s diseasept_BR
dc.subjectbiomarker, Millipore xMappt_BR
dc.subject® Luminex, cerebrospinal fluidpt_BR
dc.subjectAβ42pt_BR
dc.subjecttaupt_BR
dc.subjectINNOTESTpt_BR
dc.subject.otherDoença de Alzheimerpt_BR
dc.subject.otherProteínas taupt_BR
dc.titleMillipore xmap® luminex (hatmag-68k): an accurate and cost-effective method for evaluating alzheimer's biomarkers in cerebrospinal fluidpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.716686/fullpt_BR
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