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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/56912
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Campo DCValorIdioma
dc.creatorCláudia Ribeiropt_BR
dc.creatorMaria Goretti Moreira Guimarães Penidopt_BR
dc.creatorMilena Maria Moreira Guimarãespt_BR
dc.creatorMarcelo de Sousa Tavarespt_BR
dc.creatorBruno Das Neves Souzapt_BR
dc.creatorAnderson Ferreira Leitept_BR
dc.creatorLeonardo Martins Caldeira de Deuspt_BR
dc.creatorLucas José de Campos Machadopt_BR
dc.date.accessioned2023-07-24T19:54:10Z-
dc.date.available2023-07-24T19:54:10Z-
dc.date.issued2016-09-06-
dc.citation.volume5pt_BR
dc.citation.issue5pt_BR
dc.citation.spage437pt_BR
dc.citation.epage447pt_BR
dc.identifier.doi10.5527/wjn.v5.i5.437pt_BR
dc.identifier.issn22206124pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56912-
dc.description.resumoTo evaluate the parathyroid ultrasonography and define parameters that can predict poor response to treatment in patients with secondary hyperparathyroidism due to renal failure.METHODS:This cohort study evaluated 85 patients with chronic kidney disease stage V with parathyroid hormone levels above 800 pg/mL. All patients underwent ultrasonography of the parathyroids and the following parameters were analyzed: Demographic characteristics (etiology of chronic kidney disease, gender, age, dialysis vintage, vascular access, use of vitamin D), laboratory (calcium, phosphorus, parathyroid hormone, alkaline phosphatase, bone alkaline phosphatase), and the occurrence of bone changes, cardiovascular events and death. The χ 2 test were used to compare proportions or the Fisher exact test for small sample frequencies. Studentt-test was used to detect differences between the two groups regarding continuous variables.RESULTS: Fifty-three patients (66.4%) had parathyroid nodules with higher levels of parathyroid hormone, calcium and phosphorus. Sixteen patients underwent parathyroidectomy and had higher levels of phosphorus and calcium × phosphorus product (P = 0.03 and P = 0.006, respectively). They also had lower mortality (32% vs 68%, P = 0.01) and lower incidence of cardiovascular or cerebrovascular events (27% vs 73%,P = 0.02). Calcium× phosphorus product above 55 mg2/dL2 [RR 1.48 (1.06,2.08), P = 0.03], presence of vascular calcification [1.33(1.01, 1.76), P = 0.015] and previous occurrence of vascular events [RR 2.25 (1.27, 3.98), P < 0.001] were risk factors for mortality in this population. There was no association between the occurrence of nodules and mortality. CONCLUSION:The identification of nodules at ultrasonography strengthens the indication for parathyroidectomy in patients with secondary hyperparathyroidism due to renal failure.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofWorld Journal of Nephrology-
dc.rightsAcesso Abertopt_BR
dc.subjectSecondary hyperparathyroidismpt_BR
dc.subjectParathyroid ultrasonographypt_BR
dc.subjectCalciumpt_BR
dc.subjectPhosphoruspt_BR
dc.subjectParathyroid Hormonept_BR
dc.subjectAlkaline phosphatasept_BR
dc.subjectChronic kidney diseasept_BR
dc.subjectBone alkaline phosphatasept_BR
dc.subject.otherHiperparatireoidismo Secundáriopt_BR
dc.subject.otherSinalização do Cálciopt_BR
dc.subject.otherFósforopt_BR
dc.subject.otherHormônio Paratireóideopt_BR
dc.subject.otherAlkaline phosphatasept_BR
dc.subject.otherFosfatase Alcalinapt_BR
dc.subject.otherInsuficiência Renal Crônicapt_BR
dc.titleParathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidismpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.wjgnet.com/2220-6124/abstract/v5/i5/437.htmpt_BR
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