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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57269
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dc.creatorAntônio Lúcio Teixeirapt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorLucas Alexandre Santos Marzanopt_BR
dc.creatorAline Silva de Mirandapt_BR
dc.creatorJoao Pedro Thimotheo Batistapt_BR
dc.creatorMarina de Abreu Arrudapt_BR
dc.creatorMaíra Glória de Freitas Cardosopt_BR
dc.creatorJoão Luís Vieira Monteiro de Barrospt_BR
dc.creatorJanaína Matos Moreirapt_BR
dc.creatorPriscila Menezes Ferri Liupt_BR
dc.date.accessioned2023-07-31T20:48:28Z-
dc.date.available2023-07-31T20:48:28Z-
dc.date.issued2022-
dc.citation.issue45pt_BR
dc.citation.spage167pt_BR
dc.citation.epage191pt_BR
dc.identifier.doihttps://doi.org/10.1007/s10143-021-01588-0pt_BR
dc.identifier.issn14372320pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57269-
dc.description.resumoTraumatic brain injury (TBI) is the main cause of pediatric trauma death and disability worldwide. Recent studies have sought to identify biomarkers of TBI for the purpose of assessing functional outcomes. The aim of this systematic review was to evaluate the utility of TBI biomarkers in the pediatric population by summarizing recent fndings in the medical literature. A total of 303 articles were retrieved from our search. An initial screening to remove duplicate studies yielded 162 articles. After excluding all articles that did not meet the inclusion criteria, 56 studies were gathered. Among the 56 studies, 36 analyzed serum biomarkers; 11, neuroimaging biomarkers; and 9, cerebrospinal fuid (CSF) biomarkers. Most studies assessed biomarkers in the serum, refecting the feasibility of obtaining blood samples compared to obtaining CSF or performing neuroimaging. S100B was the most studied serum biomarker in TBI, followed by SNE and UCH-L1, whereas in CSF analysis, there was no unanimity. Among the diferent neuroimaging techniques employed, difusion tensor imag ing (DTI) was the most common, seemingly holding diagnostic power in the pediatric TBI clinical setting. The number of cross-sectional studies was similar to the number of longitudinal studies. Our data suggest that S100B measurement has high sensitivity and great promise in diagnosing pediatric TBI, ideally when associated with head CT examination and clinical decision protocols. Further large-scale longitudinal studies addressing TBI biomarkers in children are required to establish more accurate diagnostic protocols and prognostic tools.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofNeurosurgical Review-
dc.rightsAcesso Restritopt_BR
dc.subjectTraumatic brain injurypt_BR
dc.subjectPediatricspt_BR
dc.subjectBiomarkerspt_BR
dc.subjectS100Bpt_BR
dc.subjectNeuroimagingpt_BR
dc.subject.otherLesões Encefálicas Traumáticaspt_BR
dc.subject.otherPediatriapt_BR
dc.subject.otherBiomarcadores Farmacológicospt_BR
dc.subject.otherSubunidade beta da Proteína Ligante de Cálcio S100pt_BR
dc.subject.otherNeuroimagempt_BR
dc.titleTraumatic brain injury biomarkers in pediatric patients: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s10143-021-01588-0pt_BR
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