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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/58563
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dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.creatorLuize Meurerpt_BR
dc.creatorKeith Hunterpt_BR
dc.creatorPaul Michael Speightpt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorLynne Binglept_BR
dc.creatorAlan Roger Dos Santos-silvapt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorRicardo Della Colettapt_BR
dc.creatorBruno Augusto Benevenuto de Andradept_BR
dc.creatorFernanda Viviane Marianopt_BR
dc.creatorLuiz Paulo Kowalskipt_BR
dc.creatorAna Lúcia Carrinho Ayroza Rangelpt_BR
dc.date.accessioned2023-09-11T19:44:20Z-
dc.date.available2023-09-11T19:44:20Z-
dc.date.issued2016-
dc.citation.issue9pt_BR
dc.citation.spagen/apt_BR
dc.citation.epagen/apt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12438pt_BR
dc.identifier.issn09042512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/58563-
dc.description.resumoBackground Salivary gland carcinomas are uncommon neoplasms and the identification of new prognostic indicators could improve their management. HOXB7 and HOXB9 are members of the class I homeobox-containing genes important for normal embryogenesis and that are dysregulated in several human neoplasms. This study investigated HOXB7 and HOXB9 expressions in salivary gland tumourigenesis, their correlation with neoplastic proliferative and angiogenic features and their importance as prognostic markers. Methods A hundred and fifty salivary gland tumours were organized in tissue microarray and expressions of CD105, Ki67, HOXB7 and HOXB9 were determined through immunohistochemistry. Reactions were quantified and correlated with clinicopathological parameters. Results In normal glands, HOXB7 was found in basal cells, whereas HOXB9 was seen in serous acinar and scattered ductal cells. Malignancies exhibited an increased vascular density, proliferative index, HOXB7 and HOXB9 expressions when compared with pleomorphic adenoma and Warthin's tumour. Significant correlation was found between HOXB7 and CD105 (P = 0.004) in adenoid cystic carcinomas, and HOXB7 higher expression significantly correlated with the presence of paresthesia (P = 0.02). No marker exhibited a significant association with survival rates (P > 0.05). Conclusion HOXB7 and HOXB9 were expressed in normal salivary gland and were present in benign and malignant tumours derived from these structures, and HOXB7 significantly correlated with neoangiogenesis in AdCC. These findings suggest that both proteins might play a role in salivary gland tumourigenesis, but they were not significant prognostic determinants in this sample.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherParesthesiapt_BR
dc.subject.otherGene expressionpt_BR
dc.titleImmunoexpression of hoxb7 and hoxb9 in salivary gland tumours carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/abs/10.1111/jop.12438#:~:text=HOXB7%20and%20HOXB9%20were%20expressed%20in%20normal%20salivary,and%20HOXB7%20significantly%20correlated%20with%20neoangiogenesis%20in%20AdCC.pt_BR
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