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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/58678
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dc.creatorLuara Isabela dos Santospt_BR
dc.creatorThais Abdala Torrespt_BR
dc.creatorSuelen Queiroz Dinizpt_BR
dc.creatorRicardo Gonçalvespt_BR
dc.creatorGustavo Caballero-florespt_BR
dc.creatorGabriel Núñezpt_BR
dc.creatorRicardo Tostes Gazzinellipt_BR
dc.creatorKevin Joseph Maloypt_BR
dc.creatorLis Ribeiro do v. Antonellipt_BR
dc.date.accessioned2023-09-14T19:11:43Z-
dc.date.available2023-09-14T19:11:43Z-
dc.date.issued2021-
dc.citation.volume34pt_BR
dc.citation.issue2pt_BR
dc.citation.spage108613pt_BR
dc.citation.epage18pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2020.108613pt_BR
dc.identifier.issn2211-1247pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/58678-
dc.description.resumoIndividuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr−) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr− bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistence.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCell Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMetabolismopt_BR
dc.subjectMaláriapt_BR
dc.subject.otherMetabolismopt_BR
dc.subject.otherMaláriapt_BR
dc.titleDisrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogenpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2211124720316028?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1127-4483pt_BR
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