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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59066
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dc.creatorPollianna Muniz Alvespt_BR
dc.creatorAline Carvalho Batistapt_BR
dc.creatorJosé Alcides Almeida Arrudapt_BR
dc.creatorDiego Antônio Costa Arantespt_BR
dc.creatorSara Ferreira dos Santos Costapt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorCassiano Francisco Weege Nonakapt_BR
dc.creatorElismauro Francisco Mendonçapt_BR
dc.date.accessioned2023-10-02T19:15:48Z-
dc.date.available2023-10-02T19:15:48Z-
dc.date.issued2018-11-27-
dc.citation.volume474pt_BR
dc.citation.spage201pt_BR
dc.citation.epage207pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00428-018-2499-6pt_BR
dc.identifier.issn14322307pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59066-
dc.description.resumoThe aim of the present study was to investigate the profile of tumor-infiltrating lymphocytes (TIL) in osteosarcomas of the jaws (OSJ). A total of 21 OSJ samples were analyzed in a retrospective and cross-sectional multicenter study. Immunohistochemistry was performed to determine the recognition of TIL such as CD4+, CD8+, granzyme B+ (GrB), programmed cell death protein+ (PD-1), and cytotoxic T lymphocyte-associated antigen 4+ (CTLA-4) in intratumoral and peripheral (stromal) regions. Positivity was determined based on the percentage and density of TIL+ per square millimeter [1 = absent (< 25 cells/mm2), 2 = low (25 to 130 cells/mm2), and 3 = high (> 130 cells/mm2)]. The association of TIL density with clinicopathologic data was determined by the Mann-Whitney test (p < 0.05). OSJ were positive for CD8+ cells in 45% (n = 9) of cases, for CD4+ cells in 30% (n = 6) of cases, and for CTLA-4+ in 4.8% (n = 1) of cases, with a score of 2 (low TIL) in all cases. All cases were negative for GrB and PD-1 (score 1). No association was observed between immune infiltrate and clinicopathologic findings. OSJ showed a microenvironment with low TIL, including failure of effectiveness of the antitumor immune response (absence of GrB+ cells), and few cells exhibited immunotherapeutic targets, such as CTLA-4 and PD-1pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - FACULDADE DE ODONTOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVirchows Archivpt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherImmunotherapypt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherOsteosarcomapt_BR
dc.subject.otherTumor microenvironmentpt_BR
dc.subject.otherLymphocytes, tumor-infiltratingpt_BR
dc.titleEvaluation of tumor-infiltrating lymphocytes in osteosarcomas of the jaws: a multicenter studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00428-018-2499-6pt_BR
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