1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59131
Full metadata record
DC FieldValueLanguage
dc.creatorFlávia Sirotheau Corrêa Pontespt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorLucas Lacerda de Souzapt_BR
dc.creatorAdriana Souza de Jesuspt_BR
dc.creatorLigia Akiko Myaharapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorDécio dos Santos Pinto Juniorpt_BR
dc.date.accessioned2023-10-04T18:49:15Z-
dc.date.available2023-10-04T18:49:15Z-
dc.date.issued2018-
dc.citation.volume47pt_BR
dc.citation.issue3pt_BR
dc.citation.spage253pt_BR
dc.citation.epage259pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12676pt_BR
dc.identifier.issn16000714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59131-
dc.description.resumoObjectives: The aim of this study was to evaluate the expression of Akt, PTEN, Mdm2 and p53 proteins in three different head and neck squamous cell carcinoma (HNSCC) cell lines (HN6, HN19 and HN30), all of them treated with epidermal growth factor (EGF) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of Hsp90 protein. Material and methods: Immunofluorescence and western blot were performed in order to analyze the location and quantification, respectively, of proteins under the action 17-AAG and EGF. Results: Treatment with EGF resulted in increased levels of Akt, PTEN and p53 in all cell lineages. The expression of Mdm2 was constant in HN30 and HN6 lineages, while in HN19 showed slightly decreased expression. Under the action 17-AAG, in HN6 and HN19, the expression of PTEN and p53 proteins was suppressed, while Akt and Mdm2 expression was reduced. Finally, in the HN30 cell lineage were absolute absence of expression of Akt, Mdm2 and p53 and decreased expression of PTEN. Conclusion: These data allow us to speculate on the particular utility of 17-AAG for HNSCC treatment through the inhibition of Akt protein expression, especially in the cases that retain the expression of PTEN protein.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectacesso restrito busca 09 09 2023 fao clínica assunto quimioterapiapt_BR
dc.subject.otherDrug therapypt_BR
dc.subject.otherSquamous cell carcinoma of head and neckpt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherEpidermal growth factorpt_BR
dc.titleEffect of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expressionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12676pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.