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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59559
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dc.creatorMarisol Miranda-Galvispt_BR
dc.creatorJucelino Freitas Jardimpt_BR
dc.creatorEstela Kaminagakura Tangopt_BR
dc.creatorAlan Roger dos Santos-Silvapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorClóvis Antonio Lopes Pintopt_BR
dc.creatorLuiz Paulo Kowalskipt_BR
dc.date.accessioned2023-10-17T19:47:41Z-
dc.date.available2023-10-17T19:47:41Z-
dc.date.issued2018-04-
dc.citation.volume125pt_BR
dc.citation.issue4pt_BR
dc.citation.spage317pt_BR
dc.citation.epage325pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.01.003pt_BR
dc.identifier.issn22124403pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59559-
dc.description.resumoObjective: Tobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients. Methods: A tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki67, cyclin D1, C-ErbB2, p21, Myc, epidermal growth factor receptor, p53, and p16 antibodies. Results: The clinicopathologic features and the immunoexpression of all tested proteins were similar in both groups. Patients with HPV-related OSSC tended to have better cancer-specific survival (CSS; 39% vs 60% 5-y CSS), and overall survival (OS; 29.2% vs 60% 5-year OS). However, this difference was not statistically significant. Conclusion: No significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and HR-HPV DNA-negative OSCC affecting young patients.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectfao clinica busca dia 09 do 09 2023 assunto proteinapt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherHuman papillomavirus virusespt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherSurvivalpt_BR
dc.subject.otherDNApt_BR
dc.titleExpression of cell cycle proteins according to HPV status in oral squamous cell carcinoma affecting young patients: a pilot studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440318300397?via%3Dihubpt_BR
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