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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59998
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dc.creatorEliane Macedo Sobrinho Santospt_BR
dc.creatorAnna Christina de Almeidapt_BR
dc.creatorHércules Otacilio Santospt_BR
dc.creatorErnane Ronie Martinspt_BR
dc.creatorFrancine Souza Alves da Fonsecapt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorCharles Martins Aguilarpt_BR
dc.creatorUlisses Alves Pereirapt_BR
dc.creatorNilson Nicolau Juniorpt_BR
dc.creatorMatheus de Souza Gomespt_BR
dc.creatorCintya Neves de Souzapt_BR
dc.creatorJoão Matheus de Almeida Ravnjakpt_BR
dc.creatorRaphael Rodrigues Portopt_BR
dc.date.accessioned2023-10-25T11:31:41Z-
dc.date.available2023-10-25T11:31:41Z-
dc.date.issued2022-
dc.citation.volume94pt_BR
dc.citation.issueSuppl 3pt_BR
dc.citation.spage1pt_BR
dc.citation.epage23pt_BR
dc.identifier.doihttps://doi.org/10.1590/0001-3765202220201380pt_BR
dc.identifier.issn1678-2690pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59998-
dc.description.resumoThis study aimed to verify the action of bioactive compounds from Brazilian plants on the leader genes involved in the SARS-CoV-2 pathway. The main human genes involved were identified in GeneCards and UNIPROT platforms, and an interaction network between leader genes was established in the STRING database. To design chemo-biology interactome networks and elucidate the interplay between genes related to the disease and bioactive plant compounds, the metasearch engine STITCH 3.1 was used. The analysis revealed that SMAD3 and CASP3 genes are leader genes, suggesting that the mechanism of action of the virus on host cells is associated with the molecular effects of these genes. Furthermore, the bioactive plant compounds, such as ascorbate, benzoquinone, ellagic acid, and resveratrol was identified as a promising adjuvant for the treatment inhibiting CASP3-mediated apoptosis. Bioactive plant compounds were verified as the main pathways enriched with KEGG and related to viral infection, assessments/immune/infections, and cell proliferation, which are potentially used for respiratory viral infections. The best-ranked molecule docked in the CASP3 binding site was rutin, while the SMAD3 binding site was resveratrol. In conclusion, this work identified several bioactive compounds from Brazilian plants showing potential antiviral functions that can directly or indirectly inhibit the new coronavirus.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciências-
dc.rightsAcesso Abertopt_BR
dc.subject.otherGenéticapt_BR
dc.subject.otherPlantas dos cerradospt_BR
dc.subject.otherCoronaviruspt_BR
dc.subject.otherCOVID-19 (Doença)pt_BR
dc.subject.otherPlantas medicinaispt_BR
dc.titleProtein-coding gene interaction network prediction of bioactive plant compound action against SARS-CoV-2: a novel hypothesis using bioinformatics analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1576-4957pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9836-4117pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5399-9522pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6139-7206pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5815-4550pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5451-140Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7180-049Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9010-8442pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7148-5813pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7352-3089pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3640-8636pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5308-682Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1603-9615pt_BR
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