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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60281
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dc.creatorBárbara B. Estevespt_BR
dc.creatorMarcella N. Melo-Bragapt_BR
dc.creatorVladimir Gorshkovpt_BR
dc.creatorThiago Verano-Bragapt_BR
dc.creatorMartin R. Larsenpt_BR
dc.creatorCélia M. F. Gontijopt_BR
dc.creatorPatricia F. Quaresmapt_BR
dc.creatorHélida Monteiro de Andradept_BR
dc.date.accessioned2023-10-30T21:03:20Z-
dc.date.available2023-10-30T21:03:20Z-
dc.date.issued2022-02-15-
dc.citation.volume12pt_BR
dc.citation.spage824968pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttps://doi.org/10.3389/fcimb.2022.824968pt_BR
dc.identifier.issn2235-2988pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60281-
dc.description.resumoLeishmania (Viannia) braziliensis is the main etiological agent of cutaneous and mucocutaneous leishmaniasis in Latin America. Non-ulcerated atypical tegumentary leishmaniasis cases caused by L. braziliensis have been reported in several regions of the American continent, including the Xacriabá indigenous reserve in São João das Missões/Minas Gerais, Brazil. Parasites isolated from these atypical clinical lesions are resistant to antimony-based therapeutics. In the present study, proteins displaying differential abundance in two strains of L. braziliensis isolated from patients with atypical lesions compared with four strains isolated from patients with typical lesions were identified using a quantitative proteomics approach based on tandem mass tag labeling (TMT) and mass spectrometry. A total of 532 (P<0.05) differentially abundant proteins were identified (298 upregulated and 234 downregulated) in strains from atypical lesions compared to strains from typical lesions. Prominent positively regulated proteins in atypical strains included those that may confer greater survival inside macrophages, proteins related to antimony resistance, and proteins associated with higher peroxidase activity. Additionally, we identified proteins showing potential as new drug and vaccine targets. Our findings contribute to the characterization of these intriguing L. braziliensis strains and provide a novel perspective on Atypical Cutaneous Leishmaniasis (ACL) cases that have been associated with therapeutic failures.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFARMACIA - FACULDADE DE FARMACIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Celular and Infection Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLeishmania braziliensispt_BR
dc.subjectAtypical woundspt_BR
dc.subjectProteomept_BR
dc.subjectAbundancept_BR
dc.subjectTMTpt_BR
dc.subjectAntimony resistancept_BR
dc.subject.otherLeishmania braziliensispt_BR
dc.subject.otherProteínaspt_BR
dc.titleCharacterization of Differentially Abundant Proteins Among Leishmania (Viannia) braziliensis Strains Isolated From Atypical or Typical Lesionspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fcimb.2022.824968/fullpt_BR
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