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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/60395
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Campo DCValorIdioma
dc.creatorIsabela Braga-Pazpt_BR
dc.creatorJoão Locke Ferreira de Araújopt_BR
dc.creatorHugo José Alvespt_BR
dc.creatorRenata Eliane de Ávilapt_BR
dc.creatorGustavo Gomes Resendept_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorRenan Pedra de Souzapt_BR
dc.creatorDiana Bahiapt_BR
dc.date.accessioned2023-10-31T21:34:03Z-
dc.date.available2023-10-31T21:34:03Z-
dc.date.issued2022-09-29-
dc.citation.volume12pt_BR
dc.citation.spage905757pt_BR
dc.citation.epagehttps://www.frontiersin.org/articles/10.3389/fcimb.2022.905757/fullpt_BR
dc.identifier.doihttps://doi.org/10.3389/fcimb.2022.905757pt_BR
dc.identifier.issn2235-2988pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60395-
dc.description.resumoIn early 2020, one of the most prevalent symptoms of SARS-CoV-2 infection was the loss of smell (anosmia), found in 60-70% of all cases. Anosmia used to occur early, concomitantly with other symptoms, and often persisted after recovery for an extended period, sometimes for months. In addition to smell disturbance, COVID-19 has also been associated with loss of taste (ageusia). The latest research suggests that SARS-CoV-2 could spread from the respiratory system to the brain through receptors in sustentacular cells localized to the olfactory epithelium. The virus invades human cells via the obligatory receptor, angiotensin-converting enzyme II (ACE2), and a priming protease, TMPRSS2, facilitating viral penetration. There is an abundant expression of both ACE2 and TMPRSS2 in sustentacular cells. In this study, we evaluated 102 COVID-19 hospitalized patients, of which 17.60% presented anosmia and 9.80% ageusia. ACE1, ACE2, and TMPRSS2 gene expression levels in nasopharyngeal tissue were obtained by RT-qPCR and measured using ΔCT analysis. ACE1 Alu287bp association was also evaluated. Logistic regression models were generated to estimate the effects of variables on ageusia and anosmia Association of ACE2 expression levels with ageusia. was observed (OR: 1.35; 95% CI: 1.098-1.775); however, no association was observed between TMPRSS2 and ACE1 expression levels and ageusia. No association was observed among the three genes and anosmia, and the Alu287bp polymorphism was not associated with any of the outcomes. Lastly, we discuss whetherthere is a bridge linking these initial symptoms, including molecular factors, to long-term COVID-19 health consequences such as cognitive dysfunctions.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetospt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCOVID-19pt_BR
dc.subjectSevere COVID-19pt_BR
dc.subjectAnosmiapt_BR
dc.subjectGenetic associationpt_BR
dc.subjectQuantitative traitpt_BR
dc.subjectLong-COVID syndromept_BR
dc.subjectCognitive dysfunctionpt_BR
dc.subject.otherCOVID-19pt_BR
dc.subject.otherGenéticapt_BR
dc.subject.otherDisfunção Cognitivapt_BR
dc.titleNegative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disorderspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fcimb.2022.905757/fullpt_BR
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