1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/60512
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorAlessandra Coutinho de Fariapt_BR
dc.creatorBernardo Henrique Mendes Correapt_BR
dc.creatorLuciana Costa Fariapt_BR
dc.creatorPaula Vieira Teixeira Vidigalpt_BR
dc.creatorMarcelo Antônio Pascoal Xavierpt_BR
dc.creatorTeresa Cristina Abreu Ferraript_BR
dc.date.accessioned2023-11-06T20:32:04Z-
dc.date.available2023-11-06T20:32:04Z-
dc.date.issued2022-
dc.citation.volume141pt_BR
dc.citation.issue3pt_BR
dc.citation.spagee2022147pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1590/1516-3180.2022.0147.R1.12072022pt_BR
dc.identifier.issn1806-9460pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60512-
dc.description.resumoBACKGROUND: Occult hepatitis B virus infection (OBI) is defined as the presence of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) in the liver of individuals with undetectable hepatitis B virus surface antigen (HBsAg) in the serum. The actual prevalence of OBI and its clinical relevance are not yet fully understood. OBJECTIVE: To evaluate the prevalence of HBV DNA in liver biopsies of HBsAg-negative patients with chronic liver disease of different etiologies in a referral center in Brazil and compare two different HBV DNA amplification protocols to detect HBV. DESIGN AND SETTING: This cross-sectional observational study was conducted at the Liver Outpatient Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, between January 2016 and December 2019. METHODS: HBV DNA was investigated in 104 liver biopsy samples from individuals with chronic liver disease of different etiologies, in whom HBsAg was undetectable in serum by nested-polymerase chain reaction (nested-PCR), using two different protocols. RESULTS: OBI, diagnosed by detecting HBV DNA using both protocols, was detected in 6.7% of the 104 individuals investigated. Both protocols showed a good reliability. CONCLUSION: In addition to the differences in the prevalence of HBV infection in different regions, variations in the polymerase chain reaction technique used for HBV DNA amplification may be responsible for the large variations in the prevalence of OBI identified in different studies. There is a need for better standardization of the diagnostic methods used to diagnose this entity.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofSao Paulo Medical Journalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHepatitis B viruspt_BR
dc.subjectLiver diseasespt_BR
dc.subjectPolymerase chain reactionpt_BR
dc.subject.otherReação em Cadeia da Polimerasept_BR
dc.subject.otherHepatopatiaspt_BR
dc.subject.otherHepatite Bpt_BR
dc.titleOccult hepatitis B virus infection in patients with chronic liver disease of different etiology in a Brazilian referral center: comparison of two different hepatitis B virus deoxyribonucleic acid amplification protocols: a cross-sectional studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/spmj/a/Fhmn4SV93wXrBRT4ywWMtPq/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7413-8710pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6610-3940pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0226-3491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7003-5159pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9081-1493pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9459-2294pt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
archivo Descripción TamañoFormato 
Occult hepatitis B virus infection in patients with chronic liver disease of different etiology in a Brazilian referral center_ comparison of two different hepatitis B virus deoxyribonucleic acid amplification proto.pdf182.42 kBAdobe PDFVisualizar/Abrir
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.