1. Repositório Institucional da UFMG
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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/60574
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorFlávia Leite Limapt_BR
dc.creatorVictor Rezende Moreirapt_BR
dc.creatorLucilaine Valéria de Souza Santospt_BR
dc.creatorLiséte Celina Langept_BR
dc.creatorAdriana Nori de Macedopt_BR
dc.creatorMarina Gonçalves Dinizpt_BR
dc.creatorCarolina Cavaliéri Gomespt_BR
dc.creatorWagner Henriques de Castropt_BR
dc.creatorGisele André Baptista Canutopt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorVictor Coutinho Bastospt_BR
dc.creatorJéssica Gardone Vitóriopt_BR
dc.creatorFilipe Fideles Duarte-Andradept_BR
dc.creatorThaís dos Santos Fontes Pereirapt_BR
dc.creatorRoberta Rayra Martins Chavespt_BR
dc.creatorAline Fernanda Cruzpt_BR
dc.creatorJúlio César Tanos de Lacerdapt_BR
dc.creatorYuri Abner Rocha Lebronpt_BR
dc.date.accessioned2023-11-07T19:05:24Z-
dc.date.available2023-11-07T19:05:24Z-
dc.date.issued2022-
dc.citation.volume28pt_BR
dc.citation.issue8pt_BR
dc.citation.spage2219pt_BR
dc.citation.epage2229pt_BR
dc.identifier.doihttps://doi.org/10.1111/odi.13913pt_BR
dc.identifier.issn1354-523Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60574-
dc.description.resumoObjective: We aimed to assess which metabolic pathways would be implicated in the phenotypic changes of the epithelial lining of odontogenic keratocyst after marsupialization, comparing pre- and post-marsupialized lesions with adjacent oral mucosa. Materials and Methods: Eighteen formalin-fixed and paraffin-embedded tissues from six subjects were divided into three paired groups: odontogenic keratocyst pre- (n = 6) and post-marsupialization (n = 6), and adjacent oral mucosa (n = 6). The metabolic pathways found in these groups were obtained by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics performed. Results: Through putative metabolite annotation followed by pathway enrichment and predictive analysis with automated algorithms (Mummichog and Gene Set Enrichment Analysis), we found differences in many cellular processes that may be involved in inflammation, oxidative stress response, keratinocyte-basal membrane attachment, differentiation, and proliferation functions, all relevant to odontogenic keratocyst pathobiology and the phenotype acquired after marsupialization.Conclusion: Our study was able to identify several metabolic pathways potentially involved in the metaplastic changes induced by marsupialization of odontogenic keratocysts. An improved comprehension of this process could pave the way for the development of targeted therapies.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Diseasespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectMarsupializationpt_BR
dc.subjectOral mucosapt_BR
dc.subjectOdontogenic keratocyst (OKC)pt_BR
dc.subjectHigh-performance liquid chromatographypt_BR
dc.subjectMass spectrometrypt_BR
dc.subjectNevoid basal cell carcinoma syndrome (NBCCS)pt_BR
dc.subject.otherTumores odontogênicospt_BR
dc.subject.otherBoca - Tumorespt_BR
dc.subject.otherMucosa bucalpt_BR
dc.subject.otherCromatografia líquida de alta eficiênciapt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.titleUnveiling metabolic changes in marsupialized odontogenic keratocyst: a pilot studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1111/odi.13913pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6368-3310pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2615-2948pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9002-3297pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5768-8729pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-4995pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0345-0376pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6182-9232pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5570-3550pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6933-8454pt_BR
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