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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60618
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dc.creatorMarco Aurelio Petroni Montezumapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorBernar Monteiro Benitespt_BR
dc.creatorCiro Dantas Soarespt_BR
dc.creatorGleyson Kleber do Amaral Silvapt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorFernando Augusto Soarespt_BR
dc.creatorRosana Lima Paganopt_BR
dc.creatorEduardo Rodrigues Fregnanipt_BR
dc.date.accessioned2023-11-07T21:12:15Z-
dc.date.available2023-11-07T21:12:15Z-
dc.date.issued2018-06-
dc.citation.volume214pt_BR
dc.citation.issue6pt_BR
dc.citation.spage907pt_BR
dc.citation.epage913pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.prp.2018.03.014pt_BR
dc.identifier.issn03440338pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60618-
dc.description.resumoAmeloblastoma is a locally aggressive neoplasm with a poorly understood pathogenesis. Therefore, the aim of this study is to investigate whether COX-2 expression is associated with ameloblastoma microvascular density (MVD) and with tumor aggressiveness. Sixty-three cases of primary ameloblastomas arranged in tissue microarray were submitted to immunohistochemistry against cyclooxigenase-2 (COX-2) and CD34. Clinicopathological parameters regarding sex, age, tumour size, tumour duration, tumour location, treatment, recurrences, radiographic features, vestibular/lingual and basal cortical disruption and follow-up data were obtained from patients' medical records and correlated with the proteins expression. The results on BRAF-V600E expression were obtained from our previous study and correlated with COX-2 and CD34 expressions. Log-rank univariate analysis and multivariate Cox regression model were done to investigate the prognostic potential of the molecular markers. Twenty-eight cases (44.4%) exhibited cytoplasmic positivity for COX-2, predominantly in the columnar peripheral cells, with a mean MVD of 2.2 vessels/mm2. COX-2 was significantly associated with recurrences (p < 0.001) and BRAF-V600E expression (p < 0.001), whereas lower MVD was associated with the use of conservative therapy (p = 0.004). Using univariate and multivariate analyses, COX-2 was significantly associated with a lower 5-year disease-free survival (DFS) rate (p < 0.001 and p = 0.012, respectively), but not with a higher MVD (p = 0.68). In conclusion, COX-2 expression in ameloblastomas is not associated with MVD, but it is significantly associated with recurrences and with a lower DFS.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPathology - Research and Practicept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectbusca dia 21 do 09 ano 2023 fao clinica restrito assunto ameloblastomapt_BR
dc.subject.otherAmeloblastomapt_BR
dc.subject.otherAntigens, CD34pt_BR
dc.subject.otherOdontogenic tumorspt_BR
dc.subject.otherCyclooxygenase 2pt_BR
dc.subject.otherMicrovascular densitypt_BR
dc.subject.otherSurvival ratept_BR
dc.titleCOX-2 as a determinant of lower disease-free survival for patients affected by ameloblastomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S034403381830092X?via%3Dihubpt_BR
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