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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61012
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dc.creatorCarla Mosconipt_BR
dc.creatorAline Carvalho Batistapt_BR
dc.creatorJosé Alcides Almeida de Arrudapt_BR
dc.creatorAna Caroline Rodrigues de Fariaspt_BR
dc.creatorGabriella Alves Quixabeira Oliveirapt_BR
dc.creatorHenrique Moura de Paulapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorElismauro Francisco Mendonçapt_BR
dc.date.accessioned2023-11-16T21:05:46Z-
dc.date.available2023-11-16T21:05:46Z-
dc.date.issued2019-01-
dc.citation.volume88pt_BR
dc.citation.spage95pt_BR
dc.citation.epage101pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2018.11.028pt_BR
dc.identifier.issn13688375pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61012-
dc.description.resumoObjectives: The objective of the present study was to investigate the expression of immune checkpoints (PD-L1, PD-L2, PD-1 and CTLA-4), immune inhibitory molecule HLA-G, markers of tumor-infiltrating lymphocytes (TIL) and dendritic cells (DC), as well as its association with clinicopathological features of adenoid cystic carcinomas (ACC) of the salivary glands. Materials and methods: Thirty-six samples from patients with ACC were analyzed immunohistochemically for the expression of PD-L1, PD-L2, PD-1, CTLA-4, HLA-G, CD8, GrB, CD1a and CD83. Positivity of HLA-G, PD-L1 and PD-L2 expression was defined by cut-offs values. CD8+ TIL was measured semiquantitatively and also using cut-off values obtained by the ROC curve considering recurrence of the lesion. Results: ACC showed low CD8+, GrB+ TIL, CD1a and CD83 populations, as well as scarce positivity for CTLA-4 and PD-1. In contrast, PD-L2 and HLA-G expression was increased, while no PD-L1 expression was detected. Interestingly, cases with lower CD8+ TIL density presented greater recurrence rates. Conclusion: Our findings suggest that the ACC microenvironment exhibits low immunogenicity, represented by low TIL and DC density. Moreover, there seems to be activation of the immune inhibitory proteins/PD-L2 and HLA-G, a scenario that may favor tumor escape from the immune system and partially explain the poor prognosis of ACC.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Oncologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectMicrobiologia oralpt_BR
dc.subjectMecanismos de evasãopt_BR
dc.subjectCisto adenóidept_BR
dc.subjectCarcinomas de glândulas salivarespt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherCarcinoma, adenoid cysticpt_BR
dc.subject.otherHead and neck neoplasmspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherMouth Neoplasmspt_BR
dc.subject.otherSalivary glandspt_BR
dc.subject.otherAssociationpt_BR
dc.subject.otherRecurrencept_BR
dc.subject.otherProteinspt_BR
dc.titleImmune microenvironment and evasion mechanisms in adenoid cystic carcinomas of salivary glandspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837518304482?via%3Dihubpt_BR
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