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http://hdl.handle.net/1843/61075
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DC Field | Value | Language |
---|---|---|
dc.creator | Aline Mansueto Mourão | pt_BR |
dc.creator | Antônio Lucio Teixeira | pt_BR |
dc.creator | Laélia Cristina Caseiro Vicente | pt_BR |
dc.creator | Mery Natali Silva Abreu | pt_BR |
dc.creator | Leonardo Cruz de Souza | pt_BR |
dc.creator | Aline Silva de Miranda | pt_BR |
dc.creator | Milene Alvarenga Rachid | pt_BR |
dc.creator | Romeu Vale Sant'Anna | pt_BR |
dc.creator | Erica Leandro Marciano Vieira | pt_BR |
dc.date.accessioned | 2023-11-17T19:27:48Z | - |
dc.date.available | 2023-11-17T19:27:48Z | - |
dc.date.issued | 2019 | - |
dc.citation.volume | 28 | pt_BR |
dc.citation.issue | 3 | pt_BR |
dc.citation.spage | 735 | pt_BR |
dc.citation.epage | 740 | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.013 | pt_BR |
dc.identifier.issn | 10523057 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/61075 | - |
dc.description.abstract | Contexto: O fator neurotrófico derivado do cérebro (BDNF) é uma neurotrofina envolvida na sobrevivência, diferenciação e maturação neuronal. Objetivo: Avaliar os níveis de BDNF na fase aguda do acidente vascular cerebral e sua potencial associação com comprometimento neurológico. Métodos: Pacientes na fase aguda do AVC isquêmico foram avaliados com as seguintes ferramentas clínicas: National Institutes of Health Stroke Scale, escala de Rankin modificada, Gugging Swallowing Screen e Alberta Stroke Program Early CT Score. Amostras de sangue foram coletadas em três momentos diferentes da internação. O BDNF foi medido através de ensaio imunoenzimático. Resultados: Pacientes que receberam alta após 10 dias apresentaram piores desfechos clínicos e níveis mais elevados de BDNF desde a admissão. Houve correlação entre os níveis de BDNF e os parâmetros clínicos. Conclusão: Os níveis de BDNF foram associados ao prognóstico clínico na fase aguda do acidente vascular cerebral isquêmico. | pt_BR |
dc.description.resumo | Context: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke. | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | ENF - DEPARTAMENTO DE ENFERMAGEM APLICADA | pt_BR |
dc.publisher.department | ICB - DEPARTAMENTO DE MORFOLOGIA | pt_BR |
dc.publisher.department | MED - DEPARTAMENTO DE FONOAUDIOLOGIA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Journal of Stroke and Cerebrovascular Diseases | - |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | Brain-derived neurotrophic factor | pt_BR |
dc.subject | Biomarker | pt_BR |
dc.subject | Stroke | pt_BR |
dc.subject | Ichemic stroke | pt_BR |
dc.subject | Stroke outcome | pt_BR |
dc.subject | Prognosis | pt_BR |
dc.subject.other | Fator neurotrófico derivado do cérebro | pt_BR |
dc.subject.other | Biomarcadores | pt_BR |
dc.subject.other | Acidente vascular cerebral | pt_BR |
dc.subject.other | Isquemia cerebral | pt_BR |
dc.subject.other | Prognóstico | pt_BR |
dc.title | Plasma levels of brain-derived neurotrophic factor are associated with prognosis in the acute phase of ischemic stroke | pt_BR |
dc.title.alternative | Níveis plasmáticos de fator neurotrófico derivado do cérebro estão associados ao prognóstico na fase aguda do acidente vascular cerebral isquêmico | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/pii/S1052305718306517?via%3Dihub | pt_BR |
Appears in Collections: | Artigo de Periódico |
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