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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61075
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dc.creatorAline Mansueto Mourãopt_BR
dc.creatorAntônio Lucio Teixeirapt_BR
dc.creatorLaélia Cristina Caseiro Vicentept_BR
dc.creatorMery Natali Silva Abreupt_BR
dc.creatorLeonardo Cruz de Souzapt_BR
dc.creatorAline Silva de Mirandapt_BR
dc.creatorMilene Alvarenga Rachidpt_BR
dc.creatorRomeu Vale Sant'Annapt_BR
dc.creatorErica Leandro Marciano Vieirapt_BR
dc.date.accessioned2023-11-17T19:27:48Z-
dc.date.available2023-11-17T19:27:48Z-
dc.date.issued2019-
dc.citation.volume28pt_BR
dc.citation.issue3pt_BR
dc.citation.spage735pt_BR
dc.citation.epage740pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.013pt_BR
dc.identifier.issn10523057pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61075-
dc.description.abstractContexto: O fator neurotrófico derivado do cérebro (BDNF) é uma neurotrofina envolvida na sobrevivência, diferenciação e maturação neuronal. Objetivo: Avaliar os níveis de BDNF na fase aguda do acidente vascular cerebral e sua potencial associação com comprometimento neurológico. Métodos: Pacientes na fase aguda do AVC isquêmico foram avaliados com as seguintes ferramentas clínicas: National Institutes of Health Stroke Scale, escala de Rankin modificada, Gugging Swallowing Screen e Alberta Stroke Program Early CT Score. Amostras de sangue foram coletadas em três momentos diferentes da internação. O BDNF foi medido através de ensaio imunoenzimático. Resultados: Pacientes que receberam alta após 10 dias apresentaram piores desfechos clínicos e níveis mais elevados de BDNF desde a admissão. Houve correlação entre os níveis de BDNF e os parâmetros clínicos. Conclusão: Os níveis de BDNF foram associados ao prognóstico clínico na fase aguda do acidente vascular cerebral isquêmico.pt_BR
dc.description.resumoContext: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neuronal survival, differentiation, and maturation. Purpose: To evaluate the levels of BDNF in the acute phase of stroke and their potential association with neurological impairment. Methods: Patients in the acute phase of ischemic stroke were evaluated with the following clinical tools: National Institutes of Health Stroke Scale, modified Rankin scale, Gugging Swallowing Screen and Alberta Stroke Program Early CT Score. Blood samples were collected at 3 different moments of hospital stay. BDNF was measured through enzyme-linked immunosorbent assay. Results: Patients who were discharged after 10 days had worse clinical outcomes and higher levels of BDNF since admission. There was correlation between BDNF levels and clinical parameters. Conclusion: BDNF levels were associated with clinical prognosis in the acute phase of ischemic stroke.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE ENFERMAGEM APLICADApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE FONOAUDIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Stroke and Cerebrovascular Diseases-
dc.rightsAcesso Restritopt_BR
dc.subjectBrain-derived neurotrophic factorpt_BR
dc.subjectBiomarkerpt_BR
dc.subjectStrokept_BR
dc.subjectIchemic strokept_BR
dc.subjectStroke outcomept_BR
dc.subjectPrognosispt_BR
dc.subject.otherFator neurotrófico derivado do cérebropt_BR
dc.subject.otherBiomarcadorespt_BR
dc.subject.otherAcidente vascular cerebralpt_BR
dc.subject.otherIsquemia cerebralpt_BR
dc.subject.otherPrognósticopt_BR
dc.titlePlasma levels of brain-derived neurotrophic factor are associated with prognosis in the acute phase of ischemic strokept_BR
dc.title.alternativeNíveis plasmáticos de fator neurotrófico derivado do cérebro estão associados ao prognóstico na fase aguda do acidente vascular cerebral isquêmicopt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1052305718306517?via%3Dihubpt_BR
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