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http://hdl.handle.net/1843/61210| Type: | Artigo de Periódico |
| Title: | Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4 |
| Authors: | Diana Paola Gómez-Mendoza Fúlvia Dias Marques Marcella Nunes de Melo Braga Richard Remko Sprenger Rubén Dario Sinisterra Millán Frank Kjeldsen Robson Augusto Souza dos Santos Thiago Verano-Braga |
| Abstract: | Myocardial infarction triggers cellular events that starts with the activation of inflammatory response and fibrogenic pathways involved in cardiac tissue remodeling. Angiotensin-(1–7) (Ang-(1–7)) is an endogenous heptapeptide from the renin-angiotensin system with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Although the beneficial aspects of Ang-(1–7) in animal models of cardiac ischemia have been reported, the molecular events underlying Ang-(1–7) cardioprotective effect remains elusive. This study investigated the impact of oral treatment with Ang-(1–7) included in hydroxypropyl β-cyclodextrin (HPβCD/Ang-(1–7)) on the cardiac proteome dysregulation due to experimental myocardial infarction. Wistar male rats were submitted to experimental myocardial infarction and treated daily with HPβCD/Ang-(1–7) during 7 days or 60 days by gavage. Our results showed that HPβCD/Ang-(1–7) treatment ameliorates the post-infarction condition due to the modulation of proteins that initially favor the resolution of inflammation and mitochondrial dysfunction. Moreover, this study reported for the first time that Ang-(1–7) treatment after experimental myocardial infarction leads to the downregulation of the C-X-C chemokine receptor type 4 (CXCR4). |
| Subject: | Angiotensina Enfarte do miocárdio Agentes antiinflamatórios Ciclodextrinas |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jprot.2019.103486 |
| URI: | http://hdl.handle.net/1843/61210 |
| Issue Date: | Sep-2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S1874391919302581 |
| metadata.dc.relation.ispartof: | Journal of Proteomics |
| Appears in Collections: | Artigo de Periódico |
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