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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61251
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dc.creatorFernando César Silvapt_BR
dc.creatorVanessa Gregório Rodriguespt_BR
dc.creatorLucienir Pains Duartept_BR
dc.creatorIvana Silva Lulapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorSidney Augusto Vieira Filhopt_BR
dc.creatorRodrigo Araújo Lima Rodriguespt_BR
dc.creatorErna Geessien Kroonpt_BR
dc.creatorPatrícia Luciana de Oliveirapt_BR
dc.creatorLuiz de Macêdo Fariaspt_BR
dc.creatorPaula Prazeres Magalhãespt_BR
dc.creatorGrácia Divina de Fátima Silvapt_BR
dc.date.accessioned2023-11-22T14:58:50Z-
dc.date.available2023-11-22T14:58:50Z-
dc.date.issued2017-
dc.citation.volume89pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1555pt_BR
dc.citation.epage1564pt_BR
dc.identifier.doihttps://doi.org/10.1590/0001-3765201720160046pt_BR
dc.identifier.issn1678-2690pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61251-
dc.description.resumoDiarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINOpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciênciaspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntidiarrhealpt_BR
dc.subjectCelastraceaept_BR
dc.subjectPentacyclic triterpenept_BR
dc.subjectAntiviral activitypt_BR
dc.subject.otherQuímica vegetalpt_BR
dc.subject.otherAgentes antiviraispt_BR
dc.subject.otherAgentes antibacterianospt_BR
dc.subject.otherDenguept_BR
dc.subject.otherDiarréiapt_BR
dc.subject.otherMaytenuspt_BR
dc.subject.otherCiclodextrinaspt_BR
dc.subject.otherRessonância magnética nuclearpt_BR
dc.titleAntidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeolpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/aabc/a/wjtnZBLw8hDT9WWf5rh5QcC/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8593-3090pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8885-6625pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0006-3987-5738pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8171-8035pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7148-4012pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2721-3826pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7462-767Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6519-8490pt_BR
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