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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61673
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dc.creatorAna Paula de Figueiredo Monteiropt_BR
dc.creatorLarissa Durães Caminhaspt_BR
dc.creatorJosé Domingos Ardissonpt_BR
dc.creatorRoberto Magalhães Paniagopt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.date.accessioned2023-12-04T14:18:35Z-
dc.date.available2023-12-04T14:18:35Z-
dc.date.issued2017-05-
dc.citation.volume163pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2016.11.091pt_BR
dc.identifier.issn1879-1344pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61673-
dc.description.resumoIn the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCarbohydrate Polymerspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCancerpt_BR
dc.subjectCitratept_BR
dc.subjectCyclodextrinpt_BR
dc.subjectIrinotecanpt_BR
dc.subjectMagnetic nanoparticlept_BR
dc.subject.otherCiclodextrinaspt_BR
dc.subject.otherNanopartículaspt_BR
dc.subject.otherSistemas de distribuição de medicamentospt_BR
dc.subject.otherCâncer - Tratamentopt_BR
dc.subject.otherPotencial zetapt_BR
dc.subject.otherLuz - Espalhamentopt_BR
dc.subject.otherTermogravimetriapt_BR
dc.subject.otherMicroscopia eletrônica - Técnicapt_BR
dc.subject.otherRaios X - Difraçãopt_BR
dc.subject.otherFourier, Espectroscopia de infravermelho por transformada dept_BR
dc.titleMagnetic nanoparticles coated with cyclodextrins and citrate for irinotecan deliverypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0144861716313698pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4202-1964pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7657-9360pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5615-3482pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0540-7163pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
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