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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61688
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dc.creatorMário José Romañachpt_BR
dc.creatorLady Paola Aristizabal Arboledapt_BR
dc.creatorLiam Robinsonpt_BR
dc.creatorWillie van Heerdenpt_BR
dc.creatorRomán Carlospt_BR
dc.creatorElena María José Román Tagerpt_BR
dc.creatorIva Loureiro Hoffmannpt_BR
dc.creatorIzilda Aparecida Cardinallipt_BR
dc.creatorRegina Maria Holanda Mendonçapt_BR
dc.creatorMarianne Vasconcelos Carvalhopt_BR
dc.creatorAllan Vinícius Martins-de-Barrospt_BR
dc.creatorAndré Caroli Rochapt_BR
dc.creatorCarla Isabelly Rodrigues-Fernandespt_BR
dc.creatorSyed Ali Khurrampt_BR
dc.creatorPaul Speightpt_BR
dc.creatorMarcio Ajudarte Lopespt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorOslei Paes Almeidapt_BR
dc.creatorAlan Roger Santos-Silvapt_BR
dc.creatorBruno Augusto Linhares Almeida Marizpt_BR
dc.creatorBruno Augusto Benevenuto Andradept_BR
dc.creatorAline Corrêa Abrahãopt_BR
dc.creatorMichelle Agostinipt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.date.accessioned2023-12-04T21:01:09Z-
dc.date.available2023-12-04T21:01:09Z-
dc.date.issued2021-
dc.citation.volume50pt_BR
dc.citation.issue6pt_BR
dc.citation.spage572pt_BR
dc.citation.epage586pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.13209pt_BR
dc.identifier.issn09042512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61688-
dc.description.resumoBackground: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with three variants (endemic, sporadic, and immunodeficiency-associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods: Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein-Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results: Of the 52 cases, BLHN was predominant in pediatric patients [43 (82.69%)] and males [43 (82.69%)], with a mean age of 11.26 ± 9.68 years (range, 1-39 years). Neck and cervical lymph nodes [14 (26.92%)], and involvement of both maxilla and mandible [8 (15.38%)], were the most common anatomical sites. Clinically, tumor/swelling [40 (31.25%)], cervical lymphadenopathy [14 (10.94%)], pain [12 (9.38%)], and bone destruction [12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 [52 (100%)], CD10 [38 (79.17%)], Bcl6 [29 (87.88%)], and c-Myc protein [18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki-67 index ranged from 90 to 100%.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectLinfomapt_BR
dc.subjectacesso restrito fao clínica Burkitt lymphoma of the head and neck: an international collaborative study título periódico Journal of oral pathology & medicine assunto Burkitt Lymphoma busca dia 28/11/2023pt_BR
dc.subject.otherBurkitt lymphomapt_BR
dc.subject.otherHeadpt_BR
dc.subject.otherNeckpt_BR
dc.subject.otherLymphoma, non-Hodgkinpt_BR
dc.subject.otherPediatricspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.titleBurkitt lymphoma of the head and neck: an international collaborative studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13209pt_BR
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