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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/61740
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Campo DCValorIdioma
dc.creatorBrenda Fernanda Moreira Castropt_BR
dc.creatorSilvia Ligório Fialhopt_BR
dc.creatorCarolina Nunes da Silvapt_BR
dc.creatorLidia Pereira Barbosa Cordeiropt_BR
dc.creatorSarah Pereira de Freitas Cenachipt_BR
dc.creatorDaniel Vítor de Vasconcelos Santospt_BR
dc.creatorRenes Resende Machadopt_BR
dc.creatorLuiz Guilherme Dias Heneinept_BR
dc.creatorLuciana Maria Silvapt_BR
dc.creatorArmando Silva-Cunhapt_BR
dc.date.accessioned2023-12-05T20:34:25Z-
dc.date.available2023-12-05T20:34:25Z-
dc.date.issued2022-
dc.citation.volume3pt_BR
dc.citation.issue2022pt_BR
dc.citation.spage100107pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.crphar.2022.100107pt_BR
dc.identifier.issn2590-2571pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61740-
dc.description.resumoUveitis is a group of sight-threatening ocular inflammatory disorders, whose mainstay of therapy is associated with severe adverse events, prompting the investigation of alternative treatments. The peptide melittin (MEL) is the major component of Apis mellifera bee venom and presents anti-inflammatory and antiangiogenic activities, with possible application in ophthalmology. This work aims to investigate the potential of intravitreal MEL in the treatment of ocular diseases involving inflammatory processes, especially uveitis. Safety of MEL was assessed in retinal cells, chick embryo chorioallantoic membranes, and rats. MEL at concentrations safe for intravitreal administration showed an antiangiogenic activity in the chorioallantoic membrane model comparable to bevacizumab, used as positive control. A protective anti-inflammatory effect in retinal cells stimulated with lipopolysaccharide (LPS) was also observed, without toxic effects. Finally, rats with bacille Calmette-Guerin- (BCG) induced uveitis treated with intravitreal MEL showed attenuated disease progression and improvement of clinical, morphological, and functional parameters, in addition to decreased levels of proinflammatory mediators in the posterior segment of the eye. These effects were comparable to the response observed with corticosteroid treatment. Therefore, MEL presents adequate safety profile for intraocular administration and has therapeutic potential as an anti-inflammatory and antiangiogenic agent for ocular diseases.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentFARMACIA - FACULDADE DE FARMACIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCurrent Research in Pharmacology and Drug Discoverypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMelittinpt_BR
dc.subjectPeptidept_BR
dc.subjectInflammationpt_BR
dc.subjectUveitispt_BR
dc.subjectAntiangiogenicpt_BR
dc.subjectEyept_BR
dc.subject.otherMelitenopt_BR
dc.subject.otherPeptídeospt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherUveítept_BR
dc.subject.otherOlhopt_BR
dc.titleLow-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S259025712200027X?via%3Dihubpt_BR
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