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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/61839
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Campo DCValorIdioma
dc.creatorGabriela Ribeiro de Araújopt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorCinthia Verônica Bardalez Lopez de Cácerespt_BR
dc.creatorAlan Roger Santos-Silvapt_BR
dc.creatorAna Carolina Prado Ribeiropt_BR
dc.creatorThaís Bianca Brandãopt_BR
dc.creatorRamiro Alejandro Tomasipt_BR
dc.creatorRuth Salomé Ferreyrapt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorSara Ferreira dos Santos Costapt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorJean Nunes dos Santospt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorBruno Augusto Benevenuto de Andradept_BR
dc.creatorMário José Romañachpt_BR
dc.creatorMichelle Agostinipt_BR
dc.date.accessioned2023-12-07T20:48:59Z-
dc.date.available2023-12-07T20:48:59Z-
dc.date.issued2021-06-09-
dc.citation.volume16pt_BR
dc.citation.issue1pt_BR
dc.citation.spage294pt_BR
dc.citation.epage303pt_BR
dc.identifier.doihttps://doi.org/10.1007/s12105-021-01336-2pt_BR
dc.identifier.issn19360568pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61839-
dc.description.resumoSmooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients' pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for α-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofHead and neck pathologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectneoplasias de cabeça e pescoçopt_BR
dc.subjectneoplasias de boca título periódico : busca dia 10 do 11 2023Head and neck pathologypt_BR
dc.subjectneoplasias mesenquimaispt_BR
dc.subjectfao clinica acesso restrito data busca 10 do 11 2023assunto Angiomyoma Leiomyoma and leiomyosarcoma (primary and metastatic) of the oral and maxillofacial region: a clinicopathological and immunohistochemical study of 27 casespt_BR
dc.subject.otherMandiblept_BR
dc.subject.otherLeiomyomapt_BR
dc.subject.otherLeiomyosarcomapt_BR
dc.subject.otherMouthpt_BR
dc.subject.otherSmooth muscle tumorpt_BR
dc.subject.otherDiagnosispt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.titleLeiomyoma and leiomyosarcoma (primary and metastatic) of the oral and maxillofacial region: a clinicopathological and immunohistochemical study of 27 casespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s12105-021-01336-2pt_BR
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