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http://hdl.handle.net/1843/61896| Type: | Artigo de Periódico |
| Title: | Prognostic factors for metastasis in cutaneous melanoma |
| Authors: | Ana Carolina Figueiredo Pereiracherobin Alberto Julius Alves Wainstein Enrico Antônio Colosimo Eugênio Marcos Andrade Goulart Flávia Vasques Bittencourt |
| Abstract: | Abstract: Background: Melanoma is a malignant neoplasia that shows high mortality when diagnosed in advanced stages. Early identification of high-risk patients for the development of melanoma metastases is the main strategy to reduce mortality. oBjective: To assess the influence of eight epidemiological and histopathologic features on the development of metastases in patients diagnosed with primary cutaneous melanoma. Methods: Our historical cohort comprised patients with invasive primary cutaneous melanoma seen between 1995 and 2012 at a public university hospital and a private oncologic surgery institution in Southeastern Brazil. The following variables were analyzed: gender, age, family history of melanoma, site of the primary tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and the mitotic index. Kaplan-Meier univariate test and multivariate Cox proportional hazard analysis were used to assess factors associated with disease-free survival. results: Five hundred and fourteen patients were enrolled. The univariate analysis identified the following significant risk factors:gender, age, site of the tumor, clinical and histologic subtype, Breslow thickness, histologic ulceration and mitotic index. Multivariate analysis included 244 patients and detected four significant prognostic factors: male gender, nodular clinical and histologic subtype, Breslow thickness > 4mm, and histologic ulceration. The mitotic index was not included in this analysis. study liMitations: Small number of patients in multivariate analysis. conclusions: The following prognostic factors to the development of melanoma metastasis were identified in the study: male gender, nodular histologic subtype, Breslow thickness > 4mm and ulceration. |
| Subject: | Melanoma Skin Neoplasms |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/abd1806-4841.20184779 |
| URI: | http://hdl.handle.net/1843/61896 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | http://dx.doi.org/10.1590/abd1806-4841.20184779 |
| metadata.dc.relation.ispartof: | Anais Brasileiros de Dermatologia |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Prognostic factors for metastasis in cutaneous melanoma pdfa.pdf | 274.5 kB | Adobe PDF | View/Open |
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