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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/61975
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Campo DCValorIdioma
dc.creatorSávio Morato Lacerda Gontijopt_BR
dc.creatorRenata Cunha Felizalipt_BR
dc.creatorPedro Pires Goulart Guimarãespt_BR
dc.creatorRobson Augusto Souza dos Santospt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.creatorPatrícia Valente Araújopt_BR
dc.date.accessioned2023-12-13T14:26:48Z-
dc.date.available2023-12-13T14:26:48Z-
dc.date.issued2017-06-
dc.citation.volume18pt_BR
dc.citation.spage252pt_BR
dc.citation.epage256pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.pdpdt.2017.03.010pt_BR
dc.identifier.issn1873-1597pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61975-
dc.description.resumoBackground: Photodynamic therapy (PDT) is an antitumour treatment that employs the combination of a photosensitive compound, oxygen and visible light. To improve the antitumour activity of PDT, the present study used the strategy of combining PDT with erlotinib (ERL), a drug frequently used in the treatment of epidermoid carcinoma. Methods: An MTT cell viability assay was used to evaluate the cytotoxicity of PDT combined with ERL on A431 epidermoid carcinoma cells in vitro. This study evaluated the cytotoxicity of the following treatments: red laser irradiation (660 nm) at different power densities (1.25–180 J/cm2), the photosensitizer methylene blue (MB) at concentrations of 0.39–100 μM, PDT (12.5 μM MB and laser power densities from 1.25 to 180 J/cm2), and PDT (12.5 μM MB and a laser density of 120 J/cm2) plus ERL (1 μM). Results: The laser power densities that were tested showed no cytotoxicity in A431 cells. MB showed a dose-dependent cytotoxicity. In PDT, an increase in the dose of light resulted in an increase in the cytotoxicity of MB. In addition, there was a sub-additive effect between PDT and ERL compared to the effect of each therapy alone. Conclusions: The sub-additive effect between PDT and ERL suggests that their combination may be an important strategy in the treatment of epidermoid carcinoma.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPhotodynamic therapypt_BR
dc.subjectMethylene bluept_BR
dc.subjectErlotinibpt_BR
dc.subjectA431 epidermoid carcinomapt_BR
dc.subject.otherFotoquimioterapiapt_BR
dc.subject.otherCarcinoma de células escamosaspt_BR
dc.subject.otherCâncer - Tratamentopt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.titleSub-additive effects of photodynamic therapy combined with erlotinib for the treatment of epidermoid carcinoma: an in vitro studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1572100016302186pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7803-4345pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4534-2779pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
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