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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/62545
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dc.creatorFrancielle Beltrãopereirapt_BR
dc.creatorWalderez Ornelas Dutrapt_BR
dc.creatorKenneth j. Gollobpt_BR
dc.creatorEdna Afonso Reispt_BR
dc.creatorAna Laura Grossi de Oliveirapt_BR
dc.creatorManoel Otávio da Costa Rochapt_BR
dc.creatorCristiane Alves da Silva Menezespt_BR
dc.date.accessioned2024-01-10T19:43:19Z-
dc.date.available2024-01-10T19:43:19Z-
dc.date.issued2018-
dc.citation.volume60pt_BR
dc.citation.issuee57pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doi10.1590/s1678-9946201860057pt_BR
dc.identifier.issn16789946pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/62545-
dc.description.resumoThe vasoactive intestinal peptide (VIP) expression is lower in cardiac chagasic patients and is related to worse cardiac function. The reduction of VIP in patients with Chagas disease may be a result of its enhanced degradation. To test this hypothesis, the tryptase and chymase expression was evaluated. We also related VIP levels with interleukin-17 (IL 17) expression since VIP may modulate IL-17 production. Plasma levels of chymase were higher in chagasic patients. Conversely, VIP/chymase and VIP/tryptase ratios were lower in chagasic patients when compared to non-infected individuals. Besides, the VIP/chymase ratio was lower in chagasic cardiac patients in comparison with the indeterminate group. A positive correlation between tryptase and chymase levels was observed in chagasic cardiac patients. In relation to IL-17, we observed a higher expression of this cytokine in the cardiac form of the disease than in the indeterminate form. IL-17/VIP ratio was higher in the cardiac form in comparison with non-infected or indeterminate form. These results suggest that the low levels of VIP observed in chagasic patients could be due to an increased production of chymase and/or to the additive effect of the interaction between chymase and tryptase in the cardiac form. Moreover, the decreased VIP expression may contribute to the increase of IL-17 in chagasic cardiac patients.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo-
dc.rightsAcesso Abertopt_BR
dc.subjectChagas diseasept_BR
dc.subjectTryptasespt_BR
dc.subjectChymasespt_BR
dc.subjectVasoactive Intestinal Peptidept_BR
dc.subjectInterleukin-17pt_BR
dc.subject.otherChagas diseasept_BR
dc.subject.otherTryptasespt_BR
dc.subject.otherChymasespt_BR
dc.subject.otherVasoactive Intestinal Peptidept_BR
dc.subject.otherInterleukin-17pt_BR
dc.titleVasoactive intestinal peptide degradation might influence interleukin-17 expression in cardiac chagasic patientspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/rimtsp/a/TgN6rnJcFxkx6gFndWbK6nB/?lang=enpt_BR
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